ArticleBioMed research international2026
Genetically Predicted 25-Hydroxyvitamin D Levels on Hypothyroidism: A Two-Sample Mendelian Randomization.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Genetically Predicted 25-Hydroxyvitamin D Levels on Hypothyroidism: A Two-Sample Mendelian Randomization.BioMed research international · 2026Article
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Authors and funding
15 authors.
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Abstract
backgroundAlterations in levels of 25-hydroxyvitamin D have been associated with the risk of thyroid disease. This study uses Mendelian randomization (MR) to infer the possible causal association of 25-hydroxyvitamin D with hypothyroidism.
methodsWe performed two-sample MR using the summary statistics data from genome-wide association studies (GWAS) from populations with European ancestry to infer the causality of genetically controlled levels of 25-hydroxyvitamin D on the risk of hypothyroidism, Hashimoto's thyroiditis, and biochemical parameters of thyroid diseases. The inverse-variance-weighted (IVW) method was used as the primary method to calculate the combined effect of all SNPs. Other methods were adopted to evaluate the stability and reliability of the results. Comprehensive sensitivity analyses were conducted to ensure that none of the MR analysis's primary assumptions were violated.
resultsThe results of the IVW analysis revealed a significant causal association between higher levels of 25-hydroxyvitamin D and lower risk of hypothyroidism (beta = -0.197, 95% CI [-0.301, -0.093]; SE = 0.053, P
conclusionThe results of this two-sample MR study provide evidence supporting the potential of 25-hydroxyvitamin D supplementation in reducing the risk of hypothyroidism.
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