Evidence map›Paper›PMID 42253149›Full record

ArticleInternational journal of laboratory hematology2026

Assessment of Tfh Cells and Related Molecules in CML-CP Patients With Different Molecular Responses.

Yulian Wang, Suxia Geng, Xiaomei Chen, Lisi Huang, Xin Huang, Qiong Luo, Lingji Zeng, Ping Wu, Yuchen Zhang, Kaifan Liu and 3 more

Abstract read
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In one paragraph

Article in International journal of laboratory hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Yulian WangDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-8721-0876
Suxia GengDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Xiaomei ChenDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Lisi HuangDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Xin HuangDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Qiong LuoDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-4249-0576
Lingji ZengDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Ping WuDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yuchen ZhangDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Kaifan LiuDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Xin DuDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Jianyu WengDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Peilong LaiDepartment of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Funding

Guangdong Medical Research Foundation B2025364National Natural Science Foundation of China No.82200148National Natural Science Foundation of China No.82200205Project of Administration of Traditional Chinese Medicine of Guangdong Province 20242002
6 · The paper itself

Abstract

introductionThis study aimed to characterize T follicular helper (Tfh) cell differentiation and related molecular profiles in chronic-phase chronic myeloid leukemia (CML-CP) patients with distinct molecular responses and to explore immune correlates of treatment outcomes.

methodsPeripheral blood CD4

resultsNewly diagnosed and pre-MMR patients exhibited decreased CD4

conclusionPre-MMR CML-CP is accompanied by aberrant Tfh cell differentiation and an immunosuppressive immune signature linked to suboptimal molecular responses. Targeting immune checkpoints or modulating Tfh cell homeostasis may help improve therapeutic outcomes in CML-CP.

Indexed as

Leukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, Chronic-PhaseT Follicular Helper CellsT-Lymphocytes, Helper-InducerAdultCell DifferentiationFemaleHumansMaleMiddle AgedPositive Regulatory Domain I-Binding Factor 1Programmed Cell Death 1 ReceptorProto-Oncogene Proteins c-bcl-6Positive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-bcl-6chronic myeloid leukemiainhibitory moleculemolecular responsesT follicular helper cells

Identifiers

PMID42253149
PMCPMC13555147

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.