Evidence map›Paper›PMID 42253077›Full record

ArticleJournal of the American Chemical Society2026

Mg

Ruohe Wang, Collin Nisler, Qiang Cui, Laura Gagliardi, Jack W Szostak

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruohe WangDepartment of Chemistry, University of Chicago, Chicago, Illinois60637, United States.ORCID 0009-0000-3960-4504
Collin NislerDepartment of Chemistry, University of Chicago, Chicago, Illinois60637, United States.
Qiang CuiDepartment of Chemistry, Boston University, Boston, Massachusetts02215, United States.ORCID 0000-0001-6214-5211
Laura GagliardiDepartment of Chemistry, University of Chicago, Chicago, Illinois60637, United States.ORCID 0000-0001-5227-1396
Jack W SzostakDepartment of Chemistry, University of Chicago, Chicago, Illinois60637, United States.ORCID 0000-0003-4131-1203

Funding

Computational Analysis of Enzyme Catalysis and RegulationR35GM141930 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Qiang Cui · 2021 to 2026
$2.7M
NIGMS NIH HHS R35 GM141930
6 · The paper itself

Abstract

The nonenzymatic replication of the primordial genetic material was an essential stage in the origin of life. One intensively studied model for this process is the template-directed extension of an RNA primer with imidazolium-bridged dinucleotide substrates. This reaction is catalyzed by divalent metal ions such as Mg

Indexed as

MagnesiumRNACatalysisMolecular Dynamics SimulationQuantum TheoryMagnesiumRNARNA primers

Identifiers

PMID42253077
PMCPMC13281521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.