Observational studyJournal of the European Academy of Dermatology and Venereology : JEADV2026
Immune checkpoint inhibitor-induced eosinophilic fasciitis: A pharmacovigilance and EADV Task force study.
Observational study in Journal of the European Academy of Dermatology and Venereology : JEADV, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Immune checkpoint inhibitor-induced eosinophilic fasciitis: A pharmacovigilance and EADV Task force study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Observational
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Authors and funding
18 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the widespread use of immune checkpoint inhibitors (ICI), rare cutaneous immune-related adverse events (cirAEs), including ICI-induced eosinophilic fasciitis (ICI-EF), are increasingly encountered. However, data on its clinical presentation and optimal therapeutic approaches remain sparse.
objectivesThis study aimed to further characterize the clinical features and outcomes of ICI-EF.
methodsThis retrospective observational study analysed clinical features, treatment strategies and outcomes of ICI-EF cases from EADV Task Force-affiliated dermatology departments, complemented by cases from the current available literature and two international pharmacovigilance databases. Patient demographics, clinical characteristics, diagnostics, treatment and follow-up data were extracted from the medical records and databases.
resultsWe present 121 ICI-EF cases from the EADV Task Force (n = 15), FPVD (n = 21), VigiBase® (n = 45) and the literature (n = 40). The most prevalent underlying malignancy in all groups was melanoma (50%), with PD-1 inhibitor monotherapy (81%) being the predominant offending drug class. The median time to ICI-EF onset was 10 months (IQR 6.8-16.3; range < 1-36). Detailed clinical information was available for 76 of the 121 cases (63%), revealing a highly variable clinical presentation. Treatment primarily involved ICI discontinuation (83%) and systemic corticosteroids (80%), followed by methotrexate (41%), intravenous immunoglobulins (12%) and mycophenolate mofetil (13%), resulting in the partial or complete resolution of ICI-EF symptoms (66%).
conclusionsICI-EF is a rare heterogeneous cirAE with varying clinical features and significant morbidity. Early recognition and timely treatment are key to ensuring ICI continuation and preserve oncologic outcomes.
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