Evidence map›Paper›PMID 42252980›Full record

ArticleEpidemiology and infection2026

Optimizing the impact of a novel spatial repellent on malaria incidence in Western Kenya.

Tiffany Huwe, Cristian Koepfli, Eric O Ochomo, John E Gimnig, Nicole L Achee, John P Grieco, Bernard Abong'o, Vincent Moshi, Alex Perkins, Sean M Moore

Abstract read
In one paragraph

Article in Epidemiology and infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tiffany Huwehttps://ror.org/00mkhxb43University of Notre Dame, USA.
Cristian Koepflihttps://ror.org/00mkhxb43University of Notre Dame, USA.ORCID 0000-0002-9354-0414
Eric O OchomoCentre for Global Health Research, https://ror.org/04r1cxt79Kenya Medical Research Institute, Kenya.
John E Gimnighttps://ror.org/042twtr12Centers for Disease Control and Prevention, USA.
Nicole L AcheeBiological Sciences, University of Notre Dame, USA.
John P GriecoBiological Sciences, University of Notre Dame, USA.
Bernard Abong'oCentre for Global Health Research, https://ror.org/04r1cxt79Kenya Medical Research Institute, Kenya.
Vincent MoshiCentre for Global Health Research, https://ror.org/04r1cxt79Kenya Medical Research Institute, Kenya.
Alex Perkinshttps://ror.org/00mkhxb43University of Notre Dame, USA.ORCID 0000-0002-7518-4014
Sean M MooreBiological Sciences, University of Notre Dame, USA.ORCID 0000-0001-9062-6100

Funding

UNITAID
6 · The paper itself

Abstract

Progress in reducing global malaria incidence has slowed in recent years, demonstrating the need for new vector control tools to complement existing interventions in reaching global malaria control targets. Spatial repellents (SRs) can reduce pathogen transmission by altering the behaviors of Anopheles spp. mosquito vectors. A recent cluster-randomized control trial in western Kenya found that SRs reduced first-time infections by 33.4% in a highly-endemic setting with substantial insecticide resistance and high coverage of insecticide treated nets. We modeled the likely impact of the SR intervention in this setting under different deployment strategies, with the goal of identifying the best overall and per-product strategies. Continuous monthly SR deployment with 100% coverage caused the greatest (45.1%) reduction in infections versus no SR, although some seasonal approaches averted more infections per SR product. Six months of SR use starting in October caused a 36.4% reduction in infections and eight months starting in September reduced infections by 44.7%. This study identified optimum and efficient SR use strategies and highlights the importance of SR protection during periods of low and increasing transmission. When resources are limited, the coverage, deployment strategy, and timing of SR deployment all play a key role in maximizing product impact.

Indexed as

AnophelesInsect RepellentsMalariaMosquito ControlMosquito VectorsAnimalsHumansIncidenceKenyaSeasonsInsect RepellentsAnophelesinsecticidemalariaspatial emanatorspatial repellentvector control

Identifiers

PMID42252980
PMCPMC13312357

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.