Evidence map›Paper›PMID 42252873›Full record

ArticleEnvironmental science & technology2026

MechoA+: A Chemical Structure Profiler Raising the Bar for the Prediction of Mechanisms of Toxic Action for Chemical Safety Assessment.

Gaspard Levet, Franklin J Bauer, Paul C Thomas, Mark T D Cronin, Jayne Roberts, Steve Gutsell, Bruno Campos, Geoff Hodges, James Firman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gaspard LevetKREATiS SAS, 23 rue du Creuzat, ZAC de St-Hubert, 38080 L'Isle d'Abeau, France.
Franklin J BauerKREATiS SAS, 23 rue du Creuzat, ZAC de St-Hubert, 38080 L'Isle d'Abeau, France.
Paul C ThomasKREATiS SAS, 23 rue du Creuzat, ZAC de St-Hubert, 38080 L'Isle d'Abeau, France.
Mark T D CroninSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, U.K.ORCID 0000-0002-6207-4158
Jayne RobertsSafety, Environmental and Regulatory Science (SERS), Unilever, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, U.K.
Steve GutsellSafety, Environmental and Regulatory Science (SERS), Unilever, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, U.K.
Bruno CamposSafety, Environmental and Regulatory Science (SERS), Unilever, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, U.K.
Geoff HodgesSafety, Environmental and Regulatory Science (SERS), Unilever, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, U.K.
James FirmanSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, U.K.ORCID 0000-0003-0319-1407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With stakeholders in chemical regulation increasingly advocating for nonanimal testing methodologies, there is a need for reliable

Indexed as

Chemical SafetyComputer SimulationQuantitative Structure-Activity RelationshipSoftware(eco)toxicitymechanism of actionmolecular initiating event (MIE)new approach methodologies (NAMs)structural profilersstructure-activtiy relationship (SAR)

Identifiers

PMID42252873
PMCPMC13296493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.