Evidence map›Paper›PMID 42252839›Full record

ArticleCancer2026

Clinicopathologic characteristics of early-onset breast cancer among unselected young Black women.

Heather K Beasley, Tiana Shah, Rory J Tinker, Anne Weidner, Lindsay Venton, Chunling Hu, Mya L Roberson, Brian D Lehmann, Fergus J Couch, Sonya Reid and 2 more

Abstract read
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In one paragraph

Article in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Heather K BeasleyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-4636-2889
Tiana ShahDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Rory J TinkerDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Anne WeidnerDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-8007-8734
Lindsay VentonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-5418-4437
Chunling HuDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Mya L RobersonLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Brian D LehmannDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Sonya ReidDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kelly MetcalfeLawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-1803-2169
Tuya PalDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

American Association for Cancer Research 22-20-73-ROBEBreast Cancer Research Foundation BCRF-030-24Breast Cancer Research Foundation HEI-25-011Burroughs Wellcome Fund G-1022376Nashville Wine AuctionSusan G. Komen SAC210105U.S. Department of Defense DOD/BCRP BC201286
6 · The paper itself

Abstract

backgroundBlack women are more likely to develop and die from early-onset breast cancer. Hereditary breast cancer (HBC) is strongly associated with early age of onset. Accordingly, HBC characteristics in young Black women were evaluated.

methodsBlack women diagnosed with invasive breast cancer at age 50 years or younger between 2005 and 2018 were recruited through the state cancer registries in Florida and Tennessee. Participants were asked to complete a questionnaire, sign medical records releases, and donate a saliva sample for free genetic testing to identify HBC germline pathogenic or likely pathogenic variant (GPV). Women with sporadic versus hereditary breast cancer were compared, based on age distribution, clinical characteristics, and family cancer history.

resultsAmong 686 participants with confirmed genetic testing, 15.3% had GPVs in breast and/or ovarian cancer predisposition genes, including BRCA1 (7.7%), BRCA2 (4.5%), PALB2 (0.9%), and ATM (0.7%), with 1.5% in other genes. Compared to the sporadic group, triple-negative breast cancers were overrepresented among BRCA1 carriers (23.6% vs. 75.5%; p < .001), and family history of breast cancer was significantly more frequent among BRCA1, BRCA2, and PALB2 carriers (all p < .05). The majority of breast cancers occurred by age 40 years in BRCA1 carriers (52.8%), compared to other genes, where age was more evenly distributed.

conclusionAmong unselected young Black women with breast cancer, our findings demonstrate that the highest frequency of HBC GPVs are in BRCA1, BRCA2, and PALB2, with identification of distinct histopathologic and demographic characteristics across HBC genes, underscoring the critical need for genetic testing in all populations.

Indexed as

Black or African AmericanBreast NeoplasmsAdultAge of OnsetBRCA1 ProteinBRCA2 ProteinFemaleFloridaGenetic Predisposition to DiseaseGenetic TestingGerm-Line MutationHumansMiddle AgedTennesseeBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanBlack womenbreast cancerbreast cancer age distributionbreast cancer characteristicsgermline pathogenic/likely pathogenic variantshereditary breast cancerregistry‐based study

Identifiers

PMID42252839
PMCPMC13244119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.