Evidence map›Paper›PMID 42252821›Full record

ArticlePediatric transplantation2026

Association Between Age at Kidney Transplantation and Risk of Early Graft Loss.

Karina Alas Marroquin, Krystle Frazier, Charles E McCulloch, Barbara Grimes, Elaine Ku

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karina Alas MarroquinUCLA Department of Internal Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0009-0000-4988-1257
Krystle FrazierUCSF Benioff Children's Physicians Pediatric Hematologist, University of California, San Francisco School of Medicine, San Francisco, California, USA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-1279-6179
Barbara GrimesDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Elaine KuDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7774-2526

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdolescence has been identified as a high-risk period for graft failure. However, existing knowledge on this topic is largely limited to long-term graft outcomes. The aim of this study was to examine the association between age at kidney transplantation and early graft loss, defined as graft failure within 3 years post-transplantation in the contemporary era.

methodsThis study was a retrospective analysis of 55 973 first-time kidney transplant recipients identified in the U.S. Renal Data System from January 1, 2005, to December 31, 2021. Adjusted Cox proportional hazards regression models were used to evaluate the association between age at transplantation and early graft failure including an interaction term for race/ethnicity.

resultsAdolescents (12 to < 18 years) and young adults (18 to < 26 years) were at the highest risk of early death-censored graft loss compared to young adults (26 to < 40 years), with hazard ratios of 1.95 (95% CI 1.74-2.17) and 2.01 (95% CI 1.86-2.17), respectively. Additionally, we found that the effect of age on early graft loss varied significantly by race, with disparities observed among Asian and Black youth.

conclusionThese findings highlight a persistently elevated risk in adolescents and young adults in the contemporary era.

Indexed as

Graft RejectionGraft SurvivalKidney Failure, ChronicKidney TransplantationAdolescentAdultAge FactorsChildFemaleHumansMaleProportional Hazards ModelsRetrospective StudiesRisk FactorsUnited StatesYoung Adultearly graft failurekidney allograftpatient non‐adherencepediatric transplantationtransition to adult care

Identifiers

PMID42252821
PMCPMC13244117

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.