Evidence map›Paper›PMID 42252724›Full record

ArticleBiomedical chromatography : BMC2026

Hydrocinnamic Acid From Candida albicans: Isolation, Characterization, and Antibacterial Activity Against Multidrug-Resistant Bacteria.

Megharethnam Kaviraj, K R Jayappriyan, Rathinam Raja

Abstract read
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Article in Biomedical chromatography : BMC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Megharethnam KavirajCentre for Advanced Studies in Botany, University of Madras, Chennai, India.ORCID https://orcid.org/0000-0002-2810-7841
K R JayappriyanCentre for Advanced Studies in Botany, University of Madras, Chennai, India.ORCID https://orcid.org/0000-0003-2350-2372
Rathinam RajaCentre for Integrative Medical Research (CIMR), Sree Balaji Medical College and Hospital, Chennai, India.ORCID https://orcid.org/0000-0002-8445-6034

Funding

Rashtriya Uchchatar Shiksha Abhiyan C3/RI & QI/PF6-Appoint/Theme-1/Group-1/2021/101
6 · The paper itself

Abstract

Microbial secondary metabolites remain an important source of structurally diverse bioactive compounds with huge therapeutic potential. Yeasts, particularly Candida albicans, possess remarkable metabolic plasticity; thus, it paves the way for identifying antibacterial substances from their extracellular metabolome as it remains underexplored. In the present study, a semi-preparative high-performance liquid chromatography (HPLC) method was developed and optimized for the efficient isolation and purification of hydrocinnamic acid (3-phenylpropionic acid) from the extracellular metabolite extract of C. albicans. The purified compound was characterized using UV-Vis, FTIR, NMR (

Indexed as

Anti-Bacterial AgentsCandida albicansPhenylpropionatesBacteriaChromatography, High Pressure LiquidDrug Resistance, Multiple, BacterialMicrobial Sensitivity Tests3-phenylpropionic acidAnti-Bacterial AgentsPhenylpropionatesantibacterial activityCandida albicansextracellular metaboliteshydrocinnamic acidsemi‐preparative HPLC

Identifiers

PMID42252724
PMCPMC13243981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.