ArticleJournal of the American Chemical Society2026
From Leuco to Blue: Photochemical Redox Amplification for Small-Molecule Immunodetection.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Sensitive enough detection of small-molecule toxins and many other target analytes remains challenging for immunoassays that rely on stoichiometric reporters or enzymatic cascades. Here we introduce an enzyme-free, light-gated amplification strategy that teams up stabilized leucomethylene blue (LMB) derivatives with antibody recognition and photoredox cycling. As a proof-of-concept, we designed a stable LMB precursor (δ-BLMB) and a BLMB-zearalenone (ZON) conjugate that undergo rapid, selective photo-oxidation to methylene blue (MB) only under the assay illumination. Electrochemical analysis has established δ-BLMB as a redox precursor to MB, while time-resolved luminescence of [Ru(phen)
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