Evidence map›Paper›PMID 42252537›Full record

ArticleMagnetic resonance in medicine2026

A Modified Balanced Steady State Free Precession Sequence for Overhauser Magnetic Resonance Imaging.

Kai Buckenmaier, Friedemann Bullinger, Georgiy Alekseevich Solomakha, Marcel Schneider, Jörn Engelmann, Philipp Pohlmann, Pavel Povolni, Laura Kuebler, André Ferreira Martins, Klaus Scheffler

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kai BuckenmaierHigh-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID https://orcid.org/0000-0002-9676-443X
Friedemann BullingerHigh-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Georgiy Alekseevich SolomakhaHigh-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Marcel SchneiderHigh-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Jörn EngelmannHigh-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Philipp PohlmannWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Eberhard-Karls University, Tübingen, Germany.ORCID https://orcid.org/0000-0002-6137-9590
Pavel PovolniHigh-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Laura KueblerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Eberhard-Karls University, Tübingen, Germany.
André Ferreira MartinsWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Eberhard-Karls University, Tübingen, Germany.ORCID https://orcid.org/0000-0002-0171-0261
Klaus SchefflerHigh-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID https://orcid.org/0000-0001-6316-8773

Funding

Deutsche Forschungsgemeinschaft 469366436Deutsche Forschungsgemeinschaft 527345502Deutsche Forschungsgemeinschaft 530130666European Research Council 834940
6 · The paper itself

Abstract

purposeLow- and ultralow-field magnetic resonance imaging (ULF MRI) have inherently low signal-to-noise ratio (SNR) by design. Overhauser dynamic nuclear polarization (ODNP) stands out as an effective solution for continuous signal enhancement. To accelerate imaging and reduce radiofrequency (RF) power deposition-which is critical due to the high-frequency RF fields required for ODNP-efficient pulse sequences are essential. For instance, a balanced steady-state free precession (bSSFP) sequence offers high signal efficiency. However, conventional bSSFP sequences are susceptible to B

methodsIn this work, we mitigated the limitations of banding artifacts by developing a modified bSSFP sequence (bSSFP180) that allows interleaved polarization and acquisition, thereby tailoring it for ODNP-enhanced ULF MRI. The unmodified and modified sequences are compared in an imaging experiment.

resultsThe proposed sequence effectively suppresses banding artifacts and demonstrates robust performance under inhomogeneous field conditions. Experimental MRI results demonstrated that bSSFP 180 achieves banding artifact-free performance.

conclusionThe banding artifact-free bSSFP180 images represent a significant advancement toward the practical and reliable use of ODNP-enhanced imaging in future biomedical applications. This is particularly relevant for MRI experiments that employ lightweight, cost-efficient, permanent magnet systems in low-field environments, which often face challenges related to field instability and inhomogeneity.

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingAlgorithmsArtifactsHumansImage EnhancementPhantoms, ImagingRadio WavesSignal Processing, Computer-AssistedSignal-To-Noise RatiobSSFPhyperpolarizationOMRIOverhauser DNPULF MRI

Identifiers

PMID42252537
PMCPMC13418953

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.