Evidence map›Paper›PMID 42252514›Full record

ArticleJournal of neuroscience research2026

Association of Interhemispheric Structural Integrity With Transcallosal Interhemispheric Inhibition in People With Chronic Stroke.

Brice Thomas Cleland, Amanda Bardhoshi, Sangeetha Madhavan

Abstract read
In one paragraph

Article in Journal of neuroscience research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brice Thomas ClelandBrain Plasticity Lab, Department of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-8227-6876
Amanda BardhoshiMidwestern University, The Chicago College of Osteopathic Medicine, Downers Grove, Illinois, USA.
Sangeetha MadhavanBrain Plasticity Lab, Department of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-6086-0027

Funding

Elucidating the role of the contralesional corticoreticulospinal tract for lower limb function after stroke.R21NS126808 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MADHAVAN, SANGEETHA · 2023 to 2024
$440k
NINDS NIH HHS R21 NS126808NINDS NIH HHS R21NS126808
6 · The paper itself

Abstract

After stroke, interhemispheric communication is often disrupted. Interhemispheric inhibition after transcranial magnetic stimulation (TMS) is thought to be mediated through the corpus callosum, but no studies have directly tested this association in people with chronic stroke. This study determined the association between TMS interhemispheric inhibition and structural integrity of the pathway connecting the bilateral motor cortices through the corpus callosum in people with chronic stroke. 33 individuals with chronic stroke [60.7 (8.3) years old; 24 male; 8.6 (6.6) years post-stroke] were enrolled. From a diffusion-weighted scan, fractional anisotropy (FA) values were extracted from the pathway between the lower limb representations of the motor cortices via the corpus callosum. TMS interhemispheric inhibition was assessed as the ipsilateral silent period (iSP) in both legs. We tested associations between FA of the corpus callosum, TMS iSP, motor impairment [Fugl Meyer Lower Extremity Assessment (FMLE)], and interlimb coordination. Fractional anisotropy values (mean [SD]: 0.35 [0.07]) were indicative of white matter damage in the corpus callosum. Ipsilateral silent periods were identified in the non-paretic (n = 31, mean [SD]: 59.9 [41.3]) and paretic TA (n = 24, mean [SD]: 60.8 [22.2]). Larger FA values were associated with shorter iSP duration in the paretic TA (R

Indexed as

Corpus CallosumMotor CortexNeural InhibitionStrokeAgedChronic DiseaseDiffusion Magnetic Resonance ImagingFemaleFunctional LateralityHumansMaleMiddle AgedNeural PathwaysTranscranial Magnetic Stimulationcorpus callosumdiffusion weighted MRIlower limbneural pathwaysstroketranscranial magnetic stimulation

Identifiers

PMID42252514
PMCPMC13325675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.