Observational studyObesity surgery2026
A Five Year Prospective Study on Recurrent Weight Gain and Six BODY-Q Health-Related Quality of Life Scales after Metabolic and Bariatric Surgery.
Observational study in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
backgroundRecurrent weight gain (RWG) after metabolic and bariatric surgery (MBS) is common, but clinically relevant thresholds remain debated. Health-related quality of life (HRQL) may provide a more patient-centered long-term outcome measure.
objectiveTo evaluate long-term HRQL trajectories according to eventual RWG phenotype, defined as < 30% versus ≥ 30% RWG after MBS.
methodsProspective multicenter cohort study at two Dutch hospitals. HRQL was assessed using six BODY-Q scales and minimal important differences (MIDs) preoperatively, at 4 months and 1-5 years postoperatively. Patients were retrospectively stratified by eventual RWG phenotype. Analyses were performed separately for laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG).
resultsOverall, 337 patients were included (LRYGB: 206 < 30% vs 19 ≥ 30%; LSG: 81 < 30% vs 31 ≥ 30%). Five-year HRQL data were available for 37-55% of patients across procedures and RWG groups. After LRYGB, longitudinal analyses showed no significant time × RWG interactions, although cross-sectional differences in physical function were observed at multiple time points (p = 0.005-0.033). After LSG, a significant time × RWG interaction was observed for physical function (p = 0.043), whereas differences in body image and psychological well-being at year 4 (p = 0.018) were isolated findings. MID achievement was largely similar between groups.
conclusionLong-term HRQL improvements and MID-based indicators of patient-perceived benefit were sustained after MBS in both eventual RWG groups. Physical function showed a significant time × RWG interaction after LSG, whereas longitudinal HRQL trajectories after LRYGB were comparable between RWG groups. Findings should be interpreted as associations with eventual RWG phenotype, particularly given the small ≥ 30% RWG subgroup after LRYGB (N = 19). KEY POINTS: • Both patients who eventually developed < 30% and ≥ 30% RWG sustained HRQL improvements over five years; • Associations between RWG and physical function differed between procedures, with cross-sectional differences after LRYGB and longitudinal interaction effects after LSG; • Absolute BODY-Q scores and MIDs provide complementary insights, underscoring the importance of evaluating both statistical and patient-perceived benefits after MBS.
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