Evidence map›Paper›PMID 42252350›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Assessing subcortical, brainstem and cerebellar metabolic patterns using [18F]FDG PET-CT imaging in dementia with Lewy bodies.

Daniël S L Loewenstein, Max van Grinsven, Cécile de Pont, Anne I J Arens, Paul L J Dautzenberg, Astrid M van Strien, Osama Sabri, Swen Hesse, Michael Rullmann, Dylan Henssen and 1 more

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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Daniël S L LoewensteinDepartment of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 EZ, Nijmegen, The Netherlands. Daniel.loewenstein@radboudumc.nl.
Max van GrinsvenDepartment of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 EZ, Nijmegen, The Netherlands.
Cécile de PontDepartment of Medical Imaging, Jeroen Bosch Hospital, 's Hertogenbosch, the Netherlands.
Anne I J ArensDepartment of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 EZ, Nijmegen, The Netherlands.
Paul L J DautzenbergDepartment of Geriatrics, Jeroen Bosch Hospital, 's Hertogenbosch, the Netherlands.
Astrid M van StrienDepartment of Geriatrics, Jeroen Bosch Hospital, 's Hertogenbosch, the Netherlands.
Osama SabriDepartment of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany.
Swen HesseDepartment of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany.
Michael RullmannDepartment of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany.
Dylan HenssenDepartment of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 EZ, Nijmegen, The Netherlands.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

purposeNumerous clinical features of Dementia with Lewy Bodies (DLB) are attributed to dysfunction in subcortical anatomy. Despite this, [

methodsPatients diagnosed with probable DLB were included from both a prospectively maintained regional database (n = 33), and the ADNI database (n = 43). Using statistical parametric mapping (SPM) analysis, metabolic activity was compared with a cohort of subjects exhibiting normal brain metabolism (n = 19). A sub-analysis was conducted with disease progression included as a covariate.

resultsHypermetabolism was observed in various subcortical regions, notably in the dentate nucleus, anterolateral thalamus, and regions of the superior cerebellar peduncle. Increased metabolism was also detected in the mesencephalic tectum, likely representing heightened activity in the superior colliculus. All findings were reproduced in the ADNI cohort and were found to be dependent on the DLB disease stage. Additionally, the well-established cortical hypometabolic signature of DLB pathology was evident, validating our methods and findings.

conclusionIncreased metabolic activity is evident in a variety of brainstem, cerebellar, and subcortical regions in patients with DLB. The dentatorubrothalamic tract, in particular, emerges as a structure of interest that connects these structures and potentially helps in understanding DLB pathophysiology. Correction for disease stage eliminated this pattern, suggesting a driver associated with disease progression.

Indexed as

Brain StemCerebellumFluorodeoxyglucose F18Lewy Body DiseasePositron Emission Tomography Computed TomographyAgedAged, 80 and overFemaleHumansMaleRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsDementia with Lewy bodiesDentatorubrothalamic tractFDG PETNeurodegenerative disordersNeuroimagingSuperior cerebellar peduncleSuperior colliculusTectum mesencephali

Identifiers

PMID42252350
PMCPMC13526053

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