ArticlePsychopharmacology2026
The influence of HINT1 protein in nucleus accumbens on aggressive behavior and anxiety-like behavior.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
objectiveHistidine triad nucleotide-binding protein 1 (HINT1), implicated in psychiatric disorders, is highly expressed in the nucleus accumbens (NAc). Although previous work has linked HINT1 to aggression and anxiety, its specific role and mechanism remain unclear. This study aimed to delineate HINT1 distribution in the NAc and its regulatory function in aggressive and anxiety-like behaviors. MATERIALS AND
methodsUsing immunofluorescence, we mapped HINT1 expression in wild-type (WT) mouse NAc. Behavioral and molecular analyses were performed on Hint1-knockout (KO) and WT littermates. Adeno-associated virus (AAV) vectors were then used to knock down (KD) or overexpress (OE) Hint1 in the NAc of WT mice for further validation.
resultsHINT1 was expressed in medium spiny neurons (MSN), microglia, oligodendrocytes and cholinergic interneurons (ChINs) in the NAc. The Hint1-KO mice exhibited increased aggression, accompanied by elevated levels of dopamine D1 receptor (D
conclusionOur findings indicate that HINT1 in the NAc inhibits aggressive behavior. Loss of Hint1 likely leads to enhanced aggression through aberrant activation of the D
Indexed as
Identifiers
42252337What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.