Evidence map›Paper›PMID 42252300›Full record

ArticleScientific reports2026

Role of Nrf2 and NQO1 genetic variants in cardiometabolic diseases: an 8-year prospective study of genetic, dietary, biochemical, and oxidative stress markers in Iranian Kurdish Adults.

Maryam Kohsari, Mohammad Amiri, Mehdi Moradinazar, Kheirollah Yari, Davood Soleimani, Ebrahim Shakiba, Zohreh Rahimi

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Maryam KohsariDepartment of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, P.O. Box: 67148-69914, Daneshgah Avenue, Kermanshah, Iran.
Mohammad AmiriDepartment of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, P.O. Box: 67148-69914, Daneshgah Avenue, Kermanshah, Iran.
Mehdi MoradinazarDepartment of Epidemiology, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Kheirollah YariMedical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Davood SoleimaniDepartment of Nutritional Sciences, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ebrahim ShakibaDepartment of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, P.O. Box: 67148-69914, Daneshgah Avenue, Kermanshah, Iran.
Zohreh RahimiDepartment of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, P.O. Box: 67148-69914, Daneshgah Avenue, Kermanshah, Iran. zohrehrahimi.biochem@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the association between Nrf2 (rs6721961) and NQO1 (rs1800566) polymorphisms and cardiometabolic diseases (CMDs) in the Kurdish population of Iran. We analyzed 509 Kurdish individuals. Biochemical markers were measured using commercial kits, and genotypes were determined via PCR-RFLP. Dietary patterns were evaluated using the food frequency questionnaire. Associations were analyzed using linear/Cox regression, margins plots, and generalized structural equation modeling (GSEM). We found biochemical, oxidative stress, and anthropometric parameters were significantly elevated in individuals carrying the recessive genotypes of Nrf2 and NQO1. Cox regression analysis revealed that homozygous recessive genotypes of each or both polymorphisms were strongly associated with an increased risk of hypertension (HTN) over time (HR = 2.82; 95% CI: 1.4-5.3). Similarly, carriers of the Nrf2 GT (HR = 1.75; 95% CI: 1.0-3.2) and carriers of both Nrf2 GT and NQO1 CT (HR = 3.15; 95% CI: 1.7-5.9) were significantly linked to a higher risk of type 2 diabetes mellitus (T2DM). According to GSEM analysis, Nrf2 GT and NQO1 (CT and TT) genotypes indirectly increased the risk of cardiovascular disease through inflammatory and oxidative stress pathways, fatty liver index, and dyslipidemia. This study demonstrates Nrf2 (rs6721961) and NQO1 (rs1800566) polymorphisms are significantly associated with an increased risk of CMDs, particularly HTN and T2DM, primarily through oxidative stress, inflammation, and metabolic dysregulation. These findings highlight the potential role of redox-related genetic variants in early risk prediction and personalized prevention strategies among genetically susceptible populations.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2NAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2Oxidative StressAdultBiomarkersDietFemaleGenetic Predisposition to DiseaseGenotypeHumansHypertensionIranMaleMiddle AgedBiomarkersNAD(P)H Dehydrogenase (Quinone)NFE2L2 protein, humanNF-E2-Related Factor 2NQO1 protein, humanCardiometabolic diseasesInflammationMetabolic dysregulationOxidative stressPolymorphisms

Identifiers

PMID42252300
PMCPMC13338313

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