Evidence map›Paper›PMID 42252293›Full record

Observational studyScientific reports2026

Two-year prospective natural history study of EYS-associated retinitis pigmentosa using adaptive optics: the KEYS study.

Hiraoka Masakazu, Maeda Akiko, Yamamoto Midori, Gofas-Salas Elena, Kitahata Shohei, Yokota Satoshi, Togashi Yuki, Toshimori Masanao, Kimura Shuhei, Hirami Yasuhiko and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hiraoka MasakazuKobe City Eye Hospital, 2-1-8 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047, Hyogo, Japan. hiraoka@vision-care.jp.
Maeda AkikoKobe City Eye Hospital, 2-1-8 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047, Hyogo, Japan.
Yamamoto MidoriKobe City Eye Hospital, 2-1-8 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047, Hyogo, Japan.
Gofas-Salas ElenaSorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, Paris, 75012, France.
Kitahata ShoheiYokohama City University, Yokohama, Kanagawa, Japan.
Yokota SatoshiKobe City Eye Hospital, 2-1-8 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047, Hyogo, Japan.
Togashi YukiSanten Pharmaceutical Co., Ltd., Osaka, Osaka, Japan.
Toshimori MasanaoSanten Pharmaceutical Co., Ltd., Osaka, Osaka, Japan.
Kimura ShuheiKawasaki Medical University, Kurashiki, Okayama, Japan.
Hirami YasuhikoKobe City Eye Hospital, 2-1-8 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047, Hyogo, Japan.
Kurimoto YasuoKobe City Eye Hospital, 2-1-8 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047, Hyogo, Japan.
Gocho KiyokoKobe City Eye Hospital, 2-1-8 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was conducted to evaluate the longitudinal morphological changes in cone density (CD) in patients with the eyes shut homolog (EYS)-associated retinitis pigmentosa (RP) using adaptive optics (AO) fundus imaging and to assess its potential as a biomarker for disease progression. As a sub-analysis of the KEYS study, this prospective observational study was conducted at the Kobe Eye Center, involving 50 patients with EYS-RP; 27 eyes from 27 patients who were eligible for adaptive optics fundus imaging were included in this analysis. Ellipsoid zone (EZ) length was assessed using optical coherence tomography, and mean deviation (MD) values were obtained from Humphrey visual field testing. CD showed a significant reduction in all regions of interest as early as 6 months from baseline. In contrast, a significant decrease in EZ length was observed only at 24 months, while MD values did not exhibit significant changes throughout the observation period. AO fundus imaging demonstrated high sensitivity in detecting early structural changes in EYS-RP. These findings contribute to a deeper understanding of the natural history of the disease, and suggest that CD measurement may serve as a supplementary indicator for assessing disease progression.

Indexed as

Eye ProteinsRetinitis PigmentosaAdultDisease ProgressionFemaleFundus OculiHumansMaleMiddle AgedOphthalmoscopyProspective StudiesRetinal Cone Photoreceptor CellsTomography, Optical CoherenceYoung AdultEye ProteinsEYS protein, humanAdaptive optics ophthalmoscopyInherited retinal dystrophyPhotoreceptorRetinitis pigmentosa

Identifiers

PMID42252293
PMCPMC13486822

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.