Evidence map›Paper›PMID 42252251›Full record

SynthesisJournal of gynecologic oncology2026

Pediatric non-gestational choriocarcinoma: systematic literature review and a multicenter case series.

Lin Yang, Shen Yang, Jinghao Yan, Haiyan Cheng, Jun Feng, Xin Feng, Xiaofeng Chang, Zhiyun Zhu, Deguang Meng, Xianwei Zhang and 4 more

Abstract readCase ReportsSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of gynecologic oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Lin Yang *Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0009-0005-7975-9806
Shen Yang *Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0009-0002-4656-7195
Jinghao Yan *Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0009-0001-0199-8525
Haiyan ChengDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0009-0009-4686-959X
Jun FengDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0002-6395-4050
Xin FengDepartment of Oncology Surgery, Beijing Children's Hospital, Zhengzhou Hospital, Zhengzhou, China.ORCID https://orcid.org/0000-0001-8212-2383
Xiaofeng ChangDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0002-5513-2508
Zhiyun ZhuDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0003-2459-6091
Deguang MengDepartment of Surgical Oncology, Baoding Hospital of Beijing Children's Hospital, Baoding, China.ORCID https://orcid.org/0000-0002-1067-563X
Xianwei ZhangDepartment of Oncology Surgery, Beijing Children's Hospital, Zhengzhou Hospital, Zhengzhou, China.ORCID https://orcid.org/0000-0001-6328-5582
Hong QinDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0001-6127-4134
Huanmin WangDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID https://orcid.org/0000-0001-9558-7753
Jianguo ZhangDepartment of Pediatric Surgery, Inner Mongolia Maternal and Child Health Care Hospital, Hohhot, China. zjg3134@vip.163.com.ORCID https://orcid.org/0000-0002-8160-6738
Wei YangDepartment of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. yw092011@aliyun.com.ORCID https://orcid.org/0000-0002-4709-0555

Funding

Capital's Funds for Health Improvement and Research 2024-1-2091
6 · The paper itself

Abstract

objectiveThis study aimed to explore the key factors affecting the prognosis of pediatric non-gestational choriocarcinoma (PNGC), providing evidence for optimizing clinical treatment and prognosis evaluation.

methodsA systematic literature review was conducted based on online searches of PubMed, Science Direct, and Google Scholar. A retrospective analysis of multi-center pediatric PNGC patients was performed for the period from 2014 to 2024.

resultsAll four patients in our series achieved complete remission and long - term survival following comprehensive treatment. A total of 19 studies involving 70 patients met the inclusion and exclusion criteria for the Systematic search of the literature. Among the 74 patients in this study, 40 received comprehensive treatment. The 3-year overall survival (OS) rate was 50.8%. Univariate survival analysis indicated that age, primary tumor location, and treatment modality influenced OS. However, multivariate analysis revealed that only single - modality treatment or no treatment was associated with an unfavorable prognosis.

conclusionPNGC is a rare and aggressive disease associated with therapeutic challenges and a poor long-term prognosis. The prognosis analysis reveals that the comprehensive treatment plays a crucial role in improving the therapeutic outcome.

Indexed as

ChoriocarcinomaChoriocarcinoma, Non-gestationalUterine NeoplasmsChildChild, PreschoolCombined Modality TherapyFemaleHumansPrognosisRetrospective StudiesSurvival RateChildChoriocarcinomaCombined Modality Therapy

Identifiers

PMID42252251
PMCPMC13365736

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.