Artificial Gap Junctional Channel Inhibiting the Proliferation of Hepatocellular Carcinoma Cells.

Meng-Ke Zhang, Lu-Lu Ye, Jun-Li Hou, Mo Sun

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meng-Ke ZhangDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China.

Lu-Lu YeDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China.

Jun-Li HouDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China.

Mo SunDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China.ORCID 0000-0002-3995-3779

Funding

Fudan University FundsNational Key Research and Development Program of China 2022YFA1203401National Natural Science Foundation of China 22171052Science and Technology Commission of Shanghai Municipality 22520712300Science and Technology Commission of Shanghai Municipality 22JC1403700

6 · The paper itself

Abstract

Gap junctions play a crucial role in intercellular communication, participating in both physiological and pathological processes. Although artificial gap junctions have been developed, their physiological functions beyond basic intercellular communication remain largely unexplored. Herein, we report a functional artificial gap junctional channel system constructed via electrostatic co-assembly of an amphiphilic transmembrane channel and a hydrophilic extracellular channel. The efficient ion transport capability of the amphiphilic channel, coupled with the extensive aggregation of the hydrophilic module within the intercellular gap, enables the formation of stable intercellular junctions. Similar to natural gap junctions, these artificial channels not only mediate intercellular ion transport but also induce G1 phase cell cycle arrest and inhibit the proliferation of hepatocellular carcinoma cells. This work provides a new strategy for intervening in cell-cell communication and offers a potential therapeutic avenue for cancer and gap junction-related diseases.

Indexed as

Carcinoma, HepatocellularGap JunctionsLiver NeoplasmsCell Line, TumorCell ProliferationHumansartificial gap junctionscell cycle and proliferationintercellular communicationpillar[5]arenessupramolecular assembly

Identifiers

PMID42251683

DOI10.1002/anie.9685133

PMCPMC13383236

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.