SynthesisWorld journal of surgery2026
Nonoperative Management of Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Comparing Antibiotic Treatment and Appendectomy in Children and Adolescents.
Synthesis in World journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis systematic review with meta-analysis aims to evaluate the current evidence comparing antibiotic therapy with the surgical gold standard (appendectomy) for the treatment of uncomplicated acute appendicitis (UAA) in children and adolescents.
methodsThis systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO, CRD420251011305. MEDLINE and CENTRAL were systematically searched up to March 2025. Randomized controlled trials (RCTs) comparing antibiotic therapy and appendectomy in patients aged 0-18 years with UAA were included. Summary data were extracted from published reports of eligible RCTs. Full text eligibility and data extraction were performed independently by two reviewers. Primary outcome was the complication-free treatment success rate at 30 days. Secondary outcomes included recurrence and complicated appendicitis at surgery. Risk ratios (RR) with 95% CIs were calculated using a random effects model.
resultsOf 815 records screened, six studies met inclusion criteria and were included in the review. A clinically relevant difference emerged in terms of complication-free treatment success between the two groups (1333 participants; RR 0.90, 95% CI 0.84-0.96; I
trial registrationCRD420251011305.
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