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ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026

Image-guided brachytherapy in patients with inoperable FIGO 2009 stage IVB endometrial cancer who were not candidates for palliative surgery.

Angeles Rovirosa, Yaowen Zang, Elaine Limkin, Piotr Wojcieszek, Magdalena Stankiewicz, Barbara Segedin, Erik Van Limbergen

Abstract readMulticenter Study
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Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Angeles RovirosaFonaments Clinics Department, Faculty of Medicine, Universitat de Barcelona, C/Casanovas 153, 08036, Barcelona, Spain. rovirosa@ub.edu.ORCID http://orcid.org/0000-0002-7832-334X
Yaowen ZangCancer Center, Henan Provincial People's Hospital, Zhengzhou, 450003, China.
Elaine LimkinRadiation Oncology Department, Institut Gustave Roussy, 94805, Villejuif, France.
Piotr WojcieszekMaria Sklodowska-Curie National Research Institute of Oncology, 44-102, Gliwice, Poland.
Magdalena StankiewiczMaria Sklodowska-Curie National Research Institute of Oncology, 44-102, Gliwice, Poland.
Barbara SegedinRadiation Oncology Department, Institute of Oncology Ljubljana, Faculty of Medicine, University of Ljubljana, 1000, Ljubljana, Slovenia.
Erik Van LimbergenRadiation Oncology Department, University Hospital Gasthuisberg, 3000, Louvain, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn patients with endometrial cancer (EC) with metastases at diagnosis, palliative treatment is the only therapy considered and to our knowledge there is no literature on the evolution of these patients following external-beam-irradiation (EBRT) and image-guided brachytherapy (IGBT). We present the clinical outcomes of 11 FIGO 2009 stage-IVB EC patients treated with IGBT ± EBRT. METHODS/PATIENTS: From July 2009 to February 2018, 11 stage IVB patients were treated with IGBT ± EBRT in 4 European centres. The treatments and the outcomes of these patients were analysed. STATISTICS: Kaplan-Meier and descriptive analysis were used for analysing overall survival (OS).

resultsThe median age was 63 years (46-79) and the median follow-up was 39 months (8-128). The sites of metastases were reported in 8/11 patients: the lung in 4 patients, peritoneal and liver metastasis in one, pleural metastasis in one, bone in one and inguinal lymph nodes in one. Seven patients underwent chemotherapy (5 achieving complete response (CR)). Two patients received IGBT alone and 9 EBRT + IGBT. Three developed uterine relapse, 3 lymph node relapse and all died. Four had distant metastases and only one was alive after treatment. The OS was 69.3% at 2 and 3 years and 41.6% at 5 and 10 years.

conclusionIn this series, patients with stage IVB EC with CR after chemotherapy and treated with IGBT ± EBRT achieved an OS of 41.6% at 5 and 10 years. Local treatment with EBRT ± IGBT should be considered mainly in good responders to chemotherapy and should be validated in prospective trials including biological markers.

Indexed as

BrachytherapyEndometrial NeoplasmsRadiotherapy, Image-GuidedAgedFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm StagingPalliative CareRetrospective StudiesSurvival RateEndometrial cancerFigo 2009 stage IVBImage-guided brachytherapy

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.