ArticleAnnals of general psychiatry2026
Association between generalized anxiety disorder and health-related quality of life.
Article in Annals of general psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe objective of this study was to examine the association between generalized anxiety disorder (GAD) and health-related quality of life (HRQOL) in the general Korean population, and whether this relationship differed by multimorbidity profiles and household income.
methodsWe included 5,542 participants aged 19 years or older from the data of the 2021 Korean National Health and Nutrition Examination Survey. The GAD was assessed using the Generalized Anxiety Disorder 7-item scale (GAD-7). Participants with a GAD-7 score ≥ 10 were classified as having GAD. HRQOL was measured using the Health-related Quality of Life Instrument with 8 Items (HINT-8). Multimorbidity profiles were derived using latent class analysis. Survey-weighted regression models were used to evaluate associations and interaction effects.
resultsThe weighted prevalence of GAD was 4.23%, with a mean GAD-7 score of 1.99. The mean HINT-8 index was 0.80. Higher GAD-7 scores and the presence of GAD were consistently associated with lower HINT-8 index values. GAD was associated with increased odds of problems across all HINT-8 domains, with particularly strong associations for depression (odds ratio [OR] = 34.43) and moderate associations for memory (OR = 4.88) and sleep (OR = 4.68). Three multimorbidity profiles (Healthy, Geriatric Disease, and Cardiometabolic Disease groups) were identified, and the association between GAD-7 scores and HRQOL differed by multimorbidity profile and household income, with similar patterns observed for GAD status.
conclusionsHigher GAD-7 scores and GAD were associated with substantially poorer HRQOL across both physical and psychological domains. The strength of this relationship varied according to multimorbidity profile and socioeconomic context.
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