Evidence map›Paper›PMID 42251413›Full record

ArticleJournal of cardiothoracic surgery2026

Cardiopulmonary bypass elevates the neutrophil-to-lymphocyte ratio and reduces lymphocyte counts: a comparison of on-pump versus off-pump CABG.

Xiong-Fei Xia, Yun-Chen Zhu, Liang Zhang, Rui Bao, Dai Li, Xiao-Ming Deng, Jin-Jun Bian, Bai-Ling Li, Jia-Feng Wang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiong-Fei Xia *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Yun-Chen Zhu *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Liang Zhang *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Rui BaoDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Dai LiDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Xiao-Ming DengDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Jin-Jun BianDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Bai-Ling LiDepartment of Cardiovascular Surgery, Changhai Hospital, Naval Medical University, Shanghai, China. smmu_libailing@163.com.
Jia-Feng WangDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China. jfwang@smmu.edu.cn.

Funding

National Natural Science Foundation of China 82472186
6 · The paper itself

Abstract

objectiveTo evaluate the effects of cardiopulmonary bypass (CPB) on peripheral white blood cell counts, neutrophil surface marker expression, and neutrophil function by comparing patients undergoing on-pump CABG (ONCAB) versus off-pump CABG (OPCAB), and to identify CPB-related immunological and inflammatory alterations.

methodsPatients undergoing on-pump CABG (ONCAB) or off-pump CABG (OPCAB) were recruited. Blood samples were collected preoperatively and at 24 h postoperatively. The primary outcome was the neutrophil-to-lymphocyte ratio (NLR) measured at 24 h after surgery. Secondary outcomes included monocyte Human leukocyte antigen-DR (HLA-DR) expression, lymphocyte programmed cell death protein-1 (PD-1) expression, and neutrophil surface markers (CD11b, CD18, CXCR2, CD35, CD63, CD66b, CD88, and programmed cell death-ligand 1). Neutrophil apoptosis, reactive oxygen species (ROS) production, and plasma inflammatory mediators (interleukin-6, tumor necrosis factor-alpha, interleukin-10) were also measured. Postoperative clinical outcomes and laboratory parameters were recorded.

resultsData from 36 ONCAB patients and 18 OPCAB patients were analyzed. Postoperative NLR was significantly higher in the ONCAB group than in the OPCAB group (16.6 ± 6.1 vs. 13.1 ± 3.9; p = 0.015). This difference was attributable to lower lymphocyte counts in the ONCAB group (0.7 ± 0.2 vs. 0.8 ± 0.2 × 10

conclusionsCPB elevates the NLR after CABG primarily, accompanied by reduced level of lymphocyte count, but not neutrophil count or molecular markers of neutrophil functional. These results might reflect a higher risk of short-term complications after on-pump CABG.

Indexed as

Cardiopulmonary BypassCoronary Artery BypassCoronary Artery Bypass, Off-PumpLymphocytesNeutrophilsAgedFemaleHumansLeukocyte CountLymphocyte CountMaleMiddle AgedCardiopulmonary bypassCoronary artery bypass graftingImmunomodulationNeutrophil functionNeutrophil-lymphocyte ratio

Identifiers

PMID42251413
PMCPMC13463397

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.