Evidence map›Paper›PMID 42251399›Full record

ArticleJournal of nanobiotechnology2026

Wireless flexible patch based on ultrasound-responsive SenA@ZIF-8 release for on-demand medication of periodontitis.

Bo Peng, Jing Yang, Rui Lin, Yuling Han, Hongning Wang, Runqi Zhou, Tong Yan, Shilin Liu, Hanwei Jiang, Yunshan Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Bo Peng *College of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Jing Yang *College of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Rui Lin *School of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Yuling HanCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Hongning WangCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Runqi ZhouCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Tong YanCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Shilin LiuCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Hanwei JiangCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Yunshan LiCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Tianshu ZhangCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Yuhao PengCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China.
Xinyu XueSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China. xuexinyu@uestc.edu.cn.
Huawei ShenChongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases and Western Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, P R China. huaweishen2022@163.com.
Jinlin SongCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China. songjinlin@hospital.cqmu.edu.cn.
Ximu ZhangCollege of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, 401147, PR China. zhangximu@hospital.cqmu.edu.cn.

Funding

China Postdoctoral Science Foundation Project 2024M763912Chongqing Municipal Education Commission Key Scientific Research Project KJZD-K202500412Chongqing Natural Science Foundation General Project CSTB2024NSCQ-MSX0445Chongqing Natural Science Foundation Outstanding Young Scientist Fund CSTB2023NSCQ-JQX00062the Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering 2022KFKT002the National Natural Science Foundation of China U22A20314This research task was financially supported by National Natural Science Foundation of China General Program 82470988
6 · The paper itself

Abstract

Periodontitis is a prevalent chronic inflammatory disease that causes progressive periodontal tissue loss and systemic complications. However, conventional therapies often remove biofilms without fully resolving inflammation or regenerating tissue. Here, we report a flexible wireless ultrasonic patch loaded with ZIF-8 nanoparticles containing the anti-inflammatory antioxidant senkyunolide A (SenA@ZIF-8) for on-demand drug release. A piezoelectric transducer converts 1 MHz ultrasound into ≈ 10 V, 9 mA electrical output, heating a tridecanoic acid phase-change matrix to ≈ 43 °C to trigger SenA@ZIF-8 release. In vitro, SenA@ZIF-8 was biocompatible and outperformed free SenA in protecting periodontal ligament stem cells from H₂O₂-induced oxidative damage: it reduced intracellular ROS levels and restored the activity of antioxidant enzymes. In macrophages, ZIF-8 loading enhanced intracellular SenA uptake and markedly suppressed LPS-induced proinflammatory mediator expression while promoting M2 marker expression. In a rabbit model of ligature-induced periodontitis, repeated ultrasonic-triggered SenA@ZIF-8 delivery markedly reduced periodontal inflammation. Micro‑computed tomography (Micro-CT) and histology showed that the device-treated sites exhibited the greatest alveolar bone regeneration and collagen deposition, accompanied by minimal inflammation. This innovative MOF-based ultrasonic patch can relieve oxidative stress and inflammation through minimally invasive, precise, and on-demand drug delivery, thereby promoting periodontal regeneration. This approach has significant translational potential as an adjunct therapy to improve periodontal treatment outcomes and patient compliance.

Indexed as

BenzofuransImidazolesPeriodontitisAnimalsAnti-Inflammatory AgentsAntioxidantsDrug LiberationHumansMacrophagesMaleMetal-Organic FrameworksMiceNanoparticlesOxidative StressPeriodontal LigamentRabbitsAnti-Inflammatory AgentsAntioxidantsBenzofuransImidazolesMetal-Organic FrameworksZIF-8 metal-organic frameworkFlexible patchPeriodontitisReactive oxygen speciesSenkyunolide AUltrasonic power supplyZIF-8

Identifiers

PMID42251399
PMCPMC13471616

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.