Evidence map›Paper›PMID 42251346›Full record

ArticleBMC pulmonary medicine2026

Variability of the prognostic nutritional index within 3 months after curative resection for non-small cell lung cancer and 2-year recurrence-free survival.

Guojun Yue, Lingyun Yue, Yi Wang, Wendong Qu, Ming Gong, Hui Wang, Longfeng Gu, Wenbi Huang, Yaqian Zhao, Xi Chen and 2 more

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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12 authors.

Guojun Yue *Department of Radiotherapy and Chemotherapy, Oncology Outpatient Clinic, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Lingyun Yue *Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Yi WangDepartment of Radiotherapy and Chemotherapy, Oncology Outpatient Clinic, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Wendong QuDepartment of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Ming GongDepartment of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Hui WangDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Longfeng GuDepartment of Thoracic Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Wenbi HuangDepartment of Radiotherapy and Chemotherapy, Oncology Outpatient Clinic, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Yaqian ZhaoDepartment of Radiotherapy and Chemotherapy, Oncology Outpatient Clinic, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Xi ChenDepartment of Radiotherapy and Chemotherapy, Oncology Outpatient Clinic, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Gang ShenDepartment of Thoracic Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China.
Hu MaDepartment of Thoracic Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563006, China. mahu3z@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly recurrence after curative resection remains common in non-small cell lung cancer (NSCLC). We evaluated whether early postoperative trajectories of the prognostic nutritional index (PNI) improve risk stratification.

methodsIn a single-center prospective cohort of patients undergoing R0 resection for stage I-III NSCLC (2021-2025), 119 were enrolled; 94 who were alive and recurrence-free at 3 months with complete PNI data formed the landmark cohort. PNI was measured preoperatively and during the first 3 postoperative months and calculated as 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (/mm

resultsAmong 94 patients, 51 (54.3%) showed recovered PNI and 43 (45.7%) non-recovered PNI. During follow-up, 27 RFS events occurred, with higher event rates in the non-recovered group (41.9% vs. 17.6%; 2-year RFS 59.2% vs. 82.3%). Non-recovered PNI was independently associated with worse RFS (adjusted hazard ratio 2.3) and improved a clinical model C-index from 0.66 to 0.73. Sensitivity analyses using alternative cutoffs, continuous PNI change, complication adjustment, treatment-timing exclusions, and conservative Cox models were directionally consistent.

conclusionsFailure to recover PNI within 3 months may identify patients at higher risk of recurrence after curative NSCLC resection. Multicenter validation is required before clinical implementation.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsNutrition AssessmentAgedDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNutritional StatusPrognosisProportional Hazards ModelsProspective StudiesDynamic biomarkerNon-small cell lung cancerPostoperative recoveryPrognostic nutritional indexProspective cohortRecurrence-free survival

Identifiers

PMID42251346
PMCPMC13459173

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