Trial reportRespiratory research2026
Effects of inhaled nitric oxide on ventilation/perfusion mismatch assessed by electrical impedance tomography in intubated patients with moderate-to-severe ARDS: a prospective physiological study.
Trial report in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
12 authors.
Funding
Abstract
backgroundInhaled nitric oxide (iNO) improves oxygenation in acute respiratory distress syndrome (ARDS), but its precise physiological effects on ventilation-perfusion (V/Q) matching and inflammation over 24 h remain to be fully elucidated. To determine the effect of iNO on V/Q matching, gas exchange, and systemic inflammatory response in mechanically ventilated patients with moderate-to-severe ARDS.
methodsWe conducted a prospective, single-center, randomized controlled trial in 40 mechanically ventilated patients with moderate-to-severe ARDS (PaO
resultsForty patients were randomized (20 per group). At 24 h, the iNO group showed a significantly greater improvement in V/Q matching compared to the control group. The magnitude of reduction in both EIT-measured dead space (between-group difference, P < 0.001) and shunt (between-group difference, P < 0.001 was significantly larger in the iNO group. This physiological improvement was reflected in gas exchange: the median PaO
conclusionsIn patients with moderate-to-severe ARDS, 24-hour administration of inhaled nitric oxide significantly improves oxygenation by enhancing ventilation-perfusion matching. This effect is driven by a marked reduction in both EIT-measured shunt and dead space. This study provides a direct mechanistic rationale for iNO's physiological effects and supports the potential of using EIT to guide a more personalized therapeutic approach.
trial registrationClinicaltrials.gov; Unique identifier: ChiCTR2500113100; Retrospectively registered; Registration date: 25 November 2025.
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