Evidence map›Paper›PMID 42251056›Full record

ArticleNPJ Parkinson's disease2026

Cortico-pallidal beta dynamics underlie impaired turning in Parkinson's disease.

Poojan D Shukla, Jessica E Bath, Kenneth H Louie, Hamid Fekri Azgomi, Rithvik Ramesh, Eleni Patelaki, Jacob H Marks, Jannine P Balakid, Doris D Wang

Abstract read
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In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Poojan D ShuklaDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Jessica E BathDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA.
Kenneth H LouieDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Hamid Fekri AzgomiDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Rithvik RameshDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Eleni PatelakiDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Jacob H MarksDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Jannine P BalakidDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Doris D WangDepartment of Neurological Surgery, University of California, San Francisco, CA, USA. Doris.Wang@ucsf.edu.

Funding

Cortical basal ganglia network dynamics during human gait controlR01NS130183 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Doris Du Wang · 2023 to 2026
$1.4M
Michael J. Fox Foundation for Parkinson's Research 18649NIH HHS R01NS130183NINDS NIH HHS R01 NS130183Wellcome Trust
6 · The paper itself

Abstract

Turning while walking is one of the most common yet complex human movements, and it is frequently impaired in Parkinson's disease (PD), leading to falls and loss of independence. The neural mechanisms underlying this difficulty remain unclear. Using chronically implanted devices that simultaneously record and stimulate the brain, we repeatedly measured activity in the motor cortex and basal ganglia of five individuals with PD during natural walking and turning. Successful turns were marked by reduced beta-band activity and flexible communication between cortical and pallidal regions, whereas impaired turns showed excessive beta synchrony that rigidly constrained movement. Medication and deep brain stimulation improved turning through distinct circuit mechanisms, dopamine suppressing abnormal pallidal beta activity and its communication with the cortex, and stimulation restoring cortical flexibility. These findings reveal how dynamic cortical-basal ganglia interactions may enable complex movement and establish circuit targets for adaptive brain stimulation to reduce falls in PD.

Identifiers

PMID42251056
PMCPMC13575165

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.