ArticleNPJ biofilms and microbiomes2026
Gut commensal Parabacteroides goldsteinii-derived CDCA mediates FXR signalling to improve mucosal barrier function.
Article in NPJ biofilms and microbiomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Integrative multi-omics reveals comprehensive gut-liver-adipose metabolic changes in peak laying hens with high or low egg production.Poultry science · 2026Article
- Microbial metabolic memory in inflammatory bowel disease: microbiota-derived metabolites, host-microbe reprogramming, and relapse susceptibility.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The gut microbiome plays a crucial role in maintaining barrier integrity. However, it remains urgently needed to mining the gut microbiota that contribute to intestinal mucus barrier and to understand their biological mechanisms. In this study, the Lueyang black-boned chicken (LBC, a Chinese native breed) exhibited higher abundances of Bacteroidetes and Parabacteroides and stronger intestinal barrier function than Arbor Acres (AA, a commercial breed) broilers. Microbiota transplantation from LBC to AA broilers improved the intestinal barrier function. Bacteroides expanded the exclusive metabolic niche of Parabacteroides goldsteinii by producing small metabolites, thereby increasing P. goldsteinii abundance within the gut. P. goldsteinii was identified as the main contributor to the enhanced intestinal mucosal barrier. P. goldsteinii bio-transformed the taurochenodeoxycholic acid into chenodeoxycholic acid, promoting mucin production via farnesoid X receptor activation. Collectively, these findings highlight that the gut microbiota of LBC creates an exclusive metabolic niche for P. goldsteinii through cross-feeding, and reveal the critical role of P. goldsteinii-mediated bile acid biotransformation in enhancing intestinal mucosal barrier function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.