ArticleExperimental eye research2026
Changes in Melanopsin expression in the iris after corneal abrasion in an experimental rat model.
Article in Experimental eye research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Melanopsin is a photoreceptive protein known to be important for non-image forming functions in the retina, where it is expressed in a small subset of retinal ganglion cells. Melanopsin is also found in the iris where it contributes to the pupillary light reflex in rodents, and in other tissues where its functions are not fully understood. This study assessed temporal changes in pain behavior (orbital tightening) and melanopsin immunofluorescence in the retina and iris in a corneal abrasion model. Pain behaviors peaked at 24 h after corneal abrasion and returned to near baseline levels at 1 week. Changes in melanopsin were examined at both 24 h and 1 week in both abraded and control rats. In the retina, there was no difference in the number of melanopsin-positive cells 24 h after corneal abrasion and a small decrease at 1 week post-abrasion. In the iris, melanopsin labeling in the layers surrounding the constrictor muscle was higher in abraded animals at 24 h after injury and returned to baseline levels at 1 week, in both males and females. Morphological changes at the edge of the pupillary ruff were also observed 24 h following abrasion and returned to baseline at 1 week. Our data indicate that melanopsin expression in the iris, but not the retina, has a dynamic response to corneal abrasion that correlates with abrasion-induced changes in pain behavior and morphological changes in the pupillary ruff. Thus, both molecular and morphological changes in the iris may contribute to ocular pain and photoallodynia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.