Evidence map›Paper›PMID 42250566›Full record

ReviewCurrent opinion in genetics & development2026

Lineage tracing in gastruloids to understand determinants of early fate decisions.

Sung-Eun Park, Junhong Choi

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sung-Eun ParkDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Junhong ChoiDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. Electronic address: choij10@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Molecular recording to understand the determinants of cell fate transitions in early developmentR00HG012973 · NHGRI · SLOAN-KETTERING INST CAN RESEARCH · PI Junhong Choi · 2024 to 2026
$747k
NCI NIH HHS P30 CA008748NHGRI NIH HHS R00 HG012973
6 · The paper itself

Abstract

A central goal in developmental biology is to understand how cell fates are specified during development. Advances in stem cell-derived embryoid models, such as gastruloids, have enabled the use of powerful single-cell lineage tracing approaches that are difficult to apply in whole organisms due to the complexities of genetic engineering. Here, we highlight four recent studies that use these techniques to examine fate decisions and spatial organization in gastruloids, uncovering the interplay between cell lineage and signaling in cell fate decisions.

Indexed as

Cell DifferentiationCell LineageGastrulaAnimalsGene Expression Regulation, DevelopmentalHumansSignal Transduction

Identifiers

PMID42250566
PMCPMC13389957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.