Evidence map›Paper›PMID 42250220›Full record

ArticleCell reports2026

Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.

Gustavo A Rodriguez, Andrew Aoun, Eva F Rothenberg, C Oliver Shetler, Lorenzo Posani, Srujan V Vajram, Thomas Tedesco, Anurag Sharma, Stefano Fusi, S Abid Hussaini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Gustavo A RodriguezTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Andrew AounTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA; Burke Neurological Institute, White Plains, NY 10605, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
Eva F RothenbergTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
C Oliver ShetlerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Lorenzo PosaniDepartment of Neuroscience, Columbia University Irving Medical Center, New York, NY 10027, USA; Center for Theoretical Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Srujan V VajramTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Thomas TedescoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Anurag SharmaBurke Neurological Institute, White Plains, NY 10605, USA.
Stefano FusiDepartment of Neuroscience, Columbia University Irving Medical Center, New York, NY 10027, USA; Center for Theoretical Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY 10027, USA.
S Abid HussainiTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA; Burke Neurological Institute, White Plains, NY 10605, USA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: syh7006@med.cornell.edu.

Funding

Electrophysiological Evaluation of Brain Regions Vulnerable to Alzheimers DiseaseR01AG064066 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUSSAINI, S. ABID · 2020 to 2024
$4.2M
Entorhinal-hippocampal circuit dysfunction in AD miceR01AG050425 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUSSAINI, S. ABID · 2015 to 2019
$2.5M
Dissecting the role of the dentate gyrus microcircuit to improve cognitive discrimination in aging and Alzheimer's DiseaseRF1AG080818 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FUSI, STEFANO, HEN, RENE · 2023 to 2023
$2.5M
Impaired spatial decoding and neural population code rescaling in AD miceK01AG068598 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RODRIGUEZ, GUSTAVO A · 2020 to 2024
$532k
NIA NIH HHS K01 AG068598NIA NIH HHS R01 AG050425NIA NIH HHS R01 AG064066NIA NIH HHS RF1 AG080818
6 · The paper itself

Abstract

Advanced amyloid beta (Aβ) pathology is associated with aberrant neuronal network activity and cognitive impairment in preclinical Alzheimer's disease (AD) models. Here, we assess Aβ pathology's impact on spatial information processing in the medial entorhinal cortex (MEC) of 18-month App

Indexed as

AgingAmyloid beta-Protein PrecursorEntorhinal CortexNeuronsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsGene Knock-In TechniquesInterneuronsMaleMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein Precursoramyloid betaAPP knock-inApp NL-G-FAβ plaqueCP: neurosciencein vivo electrophysiologyMedial entorhinal cortexneuronal hyperactivityratemap stabilityspatial decodingspatial remapping

Identifiers

PMID42250220
PMCPMC13560757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.