ReviewArchives of microbiology2026
Biotherapeutic strategies for quorum quenching in Salmonella Typhi: a review.
Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing (QS) in Salmonella enterica serovar Typhi (S. Typhi) is a cell-cell communication process mediated by molecules like Autoinducer-2 (AI-2). The production and detection of these molecules are population density-dependent, regulating behaviours essential to virulence and survival. Since the QS stage lies between the initial planktonic stage and the formation of a stable, persistent biofilm, it allows the pathogen to survive and become more virulent. Eradication of S. Typhi requires investigation using effective therapeutic agents, such as biologically-derived therapeutics. Conventional antibiotics have significant limitations when used against S. Typhi. Their efficacy is often hampered by different resistance problems, and they can cause various clinical complications related to their chemical and physical properties. The prolonged use of these drugs can cause host toxicity and may fail to eradicate the pathogen. The persistence of biofilms and the emergence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) strains have rendered many existing drugs ineffective. Thus, targeting bacterial communication by simply disrupting its signalling mechanism, i.e., QS, might be a better approach for therapeutic development against biofilms. This review aims to critically evaluate current QS inhibitors (QSIs) and, more importantly, to explore the potential of developing bioorganic compounds from natural and biological sources as effective quorum quenching (QQ) agents.
Indexed as
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42250148What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.