Evidence map›Paper›PMID 42250124›Full record

ArticleEuropean journal of pediatrics2026

Sleep-related breathing disorders beyond infancy following open spina bifida repair.

Davin Lee, Danny Del Cid-Linares, Alexander Van Speybroeck, Kathryn A Smith, Ramen H Chmait, Thomas G Keens, Sally L Davidson Ward, Iris A Perez

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Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Davin LeeKeck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Danny Del Cid-LinaresDivision of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, 4650 Sunset Blvd. Mail Stop 83, Los Angeles, CA, 90027, USA.
Alexander Van SpeybroeckKeck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Kathryn A SmithKeck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Ramen H ChmaitDepartment of Obstetrics and Gynecology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Thomas G KeensKeck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Sally L Davidson WardKeck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Iris A PerezKeck School of Medicine of University of Southern California, Los Angeles, CA, USA. iaperez@chla.usc.edu.ORCID http://orcid.org/0000-0002-3233-0130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with repaired open spina bifida, there are limited data on respiratory outcomes beyond the first year of life. We hypothesize that after 1 year of age there is 1) resolution of sleep-related breathing disorders (SRBD), 2) improvement of oxygenation and 3) no difference in SRBD between prenatally vs. postnatally repaired groups. We reviewed 67 patients with repaired open spina bifida and polysomnography (PSG) after age 1 year seen at Children's Hospital Los Angeles between 2015-2025. Demographics, neural tube defect location, surgery type, PSG results, and respiratory support data were collected. There were 34/67 subjects with PSG before and after 1 year of age. Before 1 year of age, 19/34 had central sleep apnea (CSA), 33/34 had obstructive sleep apnea (OSA) and 30/34 required supplemental oxygen. At age 12 to 35 months, the prevalence of OSA (p < .001) and supplemental oxygen requirement (p = .006) decreased, however CSA persisted. There were no differences in SRBD between those with prenatal repair and postnatal repair of open spina bifida. There were 33/67 subjects with PSG after age 1 year only. In children ages 3 to 17 years, up to 92% had OSA, 11% had CSA, and 44% required supplemental oxygen.Conclusion: In patients with repaired open spina bifida, OSA and supplemental oxygen requirement improved after 1 year of age, however, the majority still had SRBD without difference between those prenatally vs. postnatally repaired. Our findings highlight the importance of continued surveillance with PSG in this population. What is Known: • Infants with prenatally or postnatally repaired open spina bifida have sleep-related breathing disorders • Current guidelines do not require formal evaluation with polysomnography as standard of care What is New: • After age 1 year, obstructive sleep apnea prevalence decreased, but persisted in the majority of patients • Oxygen supplementation requirement prevalence decreased.

Indexed as

Postoperative ComplicationsSleep Apnea SyndromesSpina Bifida CysticaAdolescentChildChild, PreschoolFemaleHumansInfantMaleOxygen Inhalation TherapyPolysomnographyPrevalenceRetrospective StudiesSleep Apnea, CentralSleep Apnea, ObstructiveMyelomeningocelePolysomnographyPostnatal repairPrenatal repairSleep-disordered breathingSpina bifida

Identifiers

PMID42250124
PMCPMC13242389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.