Evidence map›Paper›PMID 42250121›Full record

ArticleDiscover nano2026

Citrate reduced gold nanoparticles lowered lipid content in differentiated 3T3-L1 adipocytes by altering the expression of adipogenic genes.

Anelisiwe Hyera, Jyoti Rajan Sharma, Adewale Oluwaseun Fadaka, Kwazikwakhe Bethuel Gabuza, Zanele Mganto-Khuselo, Abram Madimabe Madiehe, Mervin Meyer, Nicole Remaliah Samantha Sibuyi

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In one paragraph

Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anelisiwe HyeraDepartment of Biotechnology, DSTI/Technology Innovation Agency Nanotechnology Platform, University of the Western Cape (UWC), Bellville, 7535, South Africa.
Jyoti Rajan SharmaBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, 7505, South Africa. Jyoti.Sharma@mrc.ac.za.
Adewale Oluwaseun FadakaDepartment of Biotechnology, DSTI/Technology Innovation Agency Nanotechnology Platform, University of the Western Cape (UWC), Bellville, 7535, South Africa.
Kwazikwakhe Bethuel GabuzaBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, 7505, South Africa.
Zanele Mganto-KhuseloDepartment of Biotechnology, DSTI/Technology Innovation Agency Nanotechnology Platform, University of the Western Cape (UWC), Bellville, 7535, South Africa.
Abram Madimabe MadieheDepartment of Biotechnology, DSTI/Technology Innovation Agency Nanotechnology Platform, University of the Western Cape (UWC), Bellville, 7535, South Africa.
Mervin MeyerDepartment of Biotechnology, DSTI/Technology Innovation Agency Nanotechnology Platform, University of the Western Cape (UWC), Bellville, 7535, South Africa.
Nicole Remaliah Samantha SibuyiDepartment of Biotechnology, DSTI/Technology Innovation Agency Nanotechnology Platform, University of the Western Cape (UWC), Bellville, 7535, South Africa. nsibuyi@uwc.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and related metabolic disorders are increasing at alarming rates worldwide, posing a major public health challenge. Current anti-obesity therapies are limited by toxicity and adverse side effects, highlighting the need for alternative strategies. Nanotechnology offers a promising approach, with gold nanoparticles (AuNPs) attracting significant attention in biomedical applications due to their unique physicochemical properties and potential therapeutic effects. This study investigated the anti-lipogenic effects of citrate-capped AuNPs (cAuNPs) on differentiated 3T3-L1 adipocytes. The 14 nm cAuNPs were synthesized using the citrate reduction method and characterized using UV-vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The effects of cAuNPs were evaluated on cell viability, lipid accumulation, and gene expression in 3T3-L1 cells and differentiated 3T3-L1 adipocytes. cAuNPs were non-cytotoxic to 3T3-L1 cells at concentrations up to 400 nM. Oil Red O (ORO) staining revealed a concentration-dependent reduction in lipid accumulation, with the maximal effect at 72 h. Gene expression analysis using RT

Indexed as

3T3-L1 differentiated adipocytesAnti-lipogenic effectsGold nanoparticlesNanotechnologyObesity

Identifiers

PMID42250121
PMCPMC13242325

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.