Evidence map›Paper›PMID 42250118›Full record

ReviewVeterinary research communications2026

Rickettsiosis: existing advances and future opportunities for the development of vaccines.

Hassian León-Montoya, Martha Reyes-Becerril, Carlos Angulo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hassian León-MontoyaImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur , La Paz, B.C.S., 23096, México.
Martha Reyes-BecerrilImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur , La Paz, B.C.S., 23096, México.
Carlos AnguloImmunology & Vaccinology Group and Laboratorio Nacional CONAHCYT de Generación de Vacunas Veterinarias y Servicios de Diagnóstico (LNC-GVD), Centro de Investigaciones Biológicas del Noroeste, S.C. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur , La Paz, B.C.S., 23096, México. eangulo@cibnor.mx.

Funding

Centro de Investigaciones Biológicas del Noroeste PAZA, 2026
6 · The paper itself

Abstract

Rickettsioses is a zoonotic disease caused by an intracellular bacterium transmitted through the bites of hematophagous arthropods. While antibiotics can effectively treat this disease, overuse may lead to the development of antibiotic resistance. To combat this issue, vaccine development has been pursued to address this bacterial infection. The types of vaccines formulated against Rickettsia include inactivated, live-attenuated, subunit, DNA, and nanovaccines, all of which induced immune responses, and some demonstrated protective efficacy against infectious challenges. These outcomes have encouraged new scientific efforts to develop vaccines against rickettsiosis. Therefore, this review focuses on describing Rickettsia classification, transmission, pathogenesis, and immune evasion, followed by a discussion of advancements in vaccine development against Rickettsia, detailing the antigens, synthesis and production, formulations, immunization, delivery strategies, and protective efficacy. Additionally, challenges for Rickettsia vaccines were identified and placed in perspective as future opportunities.

Indexed as

Bacterial VaccinesRickettsiaRickettsia InfectionsRickettsial VaccinesVaccine DevelopmentAnimalsHumansBacterial VaccinesRickettsial VaccinesImmunityIntracellular pathogenProtectionRickettsiaceaeVaccinationZoonoses

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.