Evidence map›Paper›PMID 42250116›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026

Association of intensive blood pressure lowering with health-related quality of life after endovascular thrombectomy: a post-hoc analysis of the ENCHANTED2/MT trial.

Renjun Gu, Manyue Ge, Zhenlin Wang, Meihua Huyan, Lijun Wang, Yu Gao, Xiaoxi Zhang, Yongwei Zhang, Lei Zhang, Zifu Li and 7 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04140110 (Second Enhanced Control of Hypertension and Thrombectomy Stroke Study), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04140110 naterminatednot on this map

Second Enhanced Control of Hypertension and Thrombectomy Stroke Study (ENCHANTED2)

TypeinterventionalSponsorThe George Institute for Global Health, ChinaRan2020 to 2022Enrolled816ConditionsAcute Ischemic StrokeArmsIntensive BP lowering
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Renjun Gu *Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Manyue Ge *Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Zhenlin Wang *Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Meihua HuyanNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Lijun WangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Yu GaoNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Xiaoxi ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Yongwei ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Lei ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Zifu LiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Pengfei XingNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Weilong HuaNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Fang ShenNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jianmin LiuNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Hongjian ShenNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. fox2shj@126.com.
Pengfei YangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. p.yang@vip.163.com.
ENCHANTED2/MT investigators

Funding

Project of Science and Technology Commission of Shanghai Municipality 22Y31900400The National Ten Thousand Talents Program SQ2022QB00715
6 · The paper itself

Abstract

background and purposeIntensive blood pressure (BP) targets of less than 120 mm Hg have been shown to worsen functional outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke. However, their effects on self-reported health-related quality of life (HRQoL) remain uncertain.

methodsThis post-hoc exploratory analysis used data from ENCHANTED2/MT, an open-label, blinded-endpoint randomized trial conducted in 44 Chinese hospitals. Adults with elevated BP within 3 h after successful reperfusion were randomized to intensive (< 120 mmHg) or less intensive (140-180 mmHg) systolic BP targets. HRQoL at 90 days was assessed using the EQ-5D-3 L and EQ visual analogue scale (EQ VAS). Functional outcome was measured by the modified Rankin Scale (mRS). Treatment effects were estimated using adjusted regression models, and causal mediation analysis was performed to explore indirect and direct pathways.

resultsOf 816 randomized patients, EQ-5D data were available in 685. At 90 days, both EQ-5D index (0.66 vs. 0.72) and EQ VAS (73.01 vs. 76.84) were lower in the more intensive BP group. Adjusted mean differences favored the less intensive treatment group: 0.06 (95% CI, 0.01 ~ 0.11; P = 0.017) for EQ-5D index and 3.49 (95% CI, 0.38 ~ 6.60; P = 0.028) for EQ VAS. Mediation analysis showed that the association of intensive BP lowering with worse HRQoL was mainly indirect via worse mRS outcomes.

conclusionsIntensive BP lowering after EVT was associated with modestly worse HRQoL at 90 days. The observed differences were small in magnitude, particularly for EQ VAS relative to commonly reported thresholds for clinical importance. These findings are consistent with less intensive BP targets after EVT and highlight the importance of incorporating patient-reported outcomes in acute stroke trials. CLINICAL

trial registrationClinicalTrials.gov number, NCT04140110 the Registration Date, 22/10/2019.

Indexed as

Antihypertensive AgentsBlood PressureEndovascular ProceduresHypertensionIschemic StrokeQuality of LifeThrombectomyAgedChinaFemaleHumansMaleMiddle AgedStrokeTreatment OutcomeAntihypertensive AgentsAcute ischaemic strokeBlood pressureClinical trialEndovascular thrombectomyEQ-5DPatient-reported outcome

Identifiers

PMID42250116

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.