Evidence map›Paper›PMID 42250113›Full record

ArticleGeroScience2026

Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study.

Kristina Ukropcova, Kay Deckers, Annemarie Koster, Joost J A de Jong, Jacobus F A Jansen, Walter H Backes, Hans H C M Savelberg, Carla van der Kallen, Miranda T Schram, Sebastian Köhler and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kristina UkropcovaAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands.
Kay DeckersAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands.
Annemarie KosterCare and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
Joost J A de JongDepartment of Radiology & Nuclear Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands.
Jacobus F A JansenDepartment of Radiology & Nuclear Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands.
Walter H BackesDepartment of Radiology & Nuclear Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands.
Hans H C M SavelbergDepartment of Nutrition and Movement Sciences, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Carla van der KallenCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Miranda T SchramCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Sebastian KöhlerAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands.
Veerle van GilsAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands. v.vangils@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0001-8240-5367

Funding

European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs 31O.041
6 · The paper itself

Abstract

Higher cardiorespiratory fitness (CRF) has been linked to healthier brain ageing, which includes preservation of white matter (WM) tracts. However, whether CRF might help preserve whole-brain WM networks and whether this varies with age remains unclear. To address this gap, we used cross-sectional data from The Maastricht Study (N = 4432, mean age 59.2 ± 8.7 years, range 40-79, 51% female). We derived CRF estimates from submaximal ergometry (VO

Indexed as

AgeingCardiorespiratory fitnessDiffusion-tensor MRILifestyleStructural connectivityWhite matter networks

Identifiers

PMID42250113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.