Evidence map›Paper›PMID 42250065›Full record

ArticleApplied biochemistry and biotechnology2026

Poly(Lactic Acid) Nanofiber Membrane Loaded with Tannins from Charred Sanguisorbae Radix with Antioxidant and Antibacterial Activities for Potential Wound Healing Applications.

Yujie Hao, Chunhua Wang, Yan Ren, Anyi Sun, Yanran Du, Xianchao Li, Huanhuan Yan, Lele Zhou, Guige Hou, Xianrui Xie and 1 more

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yujie HaoSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China.
Chunhua WangSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China.
Yan RenSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China.
Anyi SunSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China.
Yanran DuSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China.
Xianchao LiSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China.
Huanhuan YanSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China.
Lele ZhouSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China.
Guige HouSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China. guigehou@163.com.
Xianrui XieSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China. xrxie@bzmc.edu.cn.
Hongjuan LiSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Shandong Medical and Pharmaceutical University, Yantai, 264003, P. R. China. lhjczb@163.com.

Funding

Natural Science Foundation of Shandong Province ZR2025MS724Shandong Provincial Higher Education Institutions "Youth Innovation Team Plan" Project 2023KJ259Yantai Natural Science Foundation 2022XDRH026Yantai Natural Science Foundation 2023JCYJ080
6 · The paper itself

Abstract

Charred Sanguisorbae Radix (CSR) is a well-known traditional Chinese medicine clinically used to treat conditions such as burns and bleeding, with tannins being its main active ingredients. In this study, the tannins (SDT) were isolated and purified from CSR using macroporous resin. Subsequently, SDT was loaded onto a poly(lactic acid) (PLA) nanofiber membrane using electrospinning, and its potential application value as a wound dressing was evaluated. The experimental results demonstrated that the nanofiber membrane loaded with SDT exhibited strong antioxidant activity and favorable antibacterial performance, both of which were enhanced with increasing SDT concentration. Among the tested membranes, the PLA2 membrane with 9% SDT loading (90 mg SDT per 1 g PLA, mass ratio) exhibited excellent biocompatibility and could significantly promote wound closure of L929 fibroblasts in the cell scratch assay. Furthermore, the PLA2 membrane could slowly release gallic acid to continuously exert its therapeutic effect. In summary, the novel SDT-loaded PLA nanofiber membrane shows great potential as a wound dressing, providing a scientific foundation for the further application of CSR in wound healing therapy.

Indexed as

Anti-Bacterial AgentsAntioxidantsMembranes, ArtificialNanofibersPolyestersSanguisorbaTanninsWound HealingAnimalsCell LineMiceAnti-Bacterial AgentsAntioxidantsMembranes, ArtificialPolyesterspoly(lactide)TanninsCharred Sanguisorbae RadixNanofiber membranePoly(lactic acid)Tannin

Identifiers

PMID42250065

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.