Trial reportNaunyn-Schmiedeberg's archives of pharmacology2026
Phthalocyanine-based mouth gel as an adjunct to non-surgical periodontal treatment: a randomized controlled trial.
Trial report in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a standard periodontal treatment (scaling and root planing), followed by adjuvant therapy according to the = groups: Vehicle Group (n = 15), receiving local application of the FeTcPc gel vehicle; Chlorhexidine (CLX) Group (n = 16), receiving local application of 0.12% chlorhexidine gel; and FeTcPc Group (n = 16), receiving local application of 1% FeTcPc-containing gel. Clinical evaluations were performed at baseline and after 45 days. No statistically significant differences were observed between the study groups in any periodontal clinical parameters at baseline or 45 days after treatment. In the intragroup analysis, the mean probing depth (PD) and the percentage of sites with PD ≤ 3 mm and PD = 4-5 mm showed a statistically significant reduction at 45 days in both the vehicle and FeTcPc groups (p < 0.05). The percentage of sites with bleeding on probing and the plaque index demonstrated a statistically significant reduction after 45 days in all groups (p < 0.05). The use of FeTcPc mouth gel as an adjunct to non-surgical periodontal therapy did not improve the clinical periodontal parameters compared to CLX or the vehicle group in this study.
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