Long-term impact of diverting ileostomy after stoma closure on the renal function and risk factors for chronic kidney disease following colorectal tumor surgery.

Emi Ota, Jun Watanabe, Hirokazu Suwa, Yusuke Suwa, Kazuya Nakagawa, Mayumi Ozawa, Itaru Endo

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Emi OtaDepartment of Surgery, Yokosuka Kyosai Hospital, Yokosuka, Japan.

Jun WatanabeDepartment of Colorectal Surgery, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, 573-1010, Osaka, Japan. watanabe.jun@kmu.ac.jp.

Hirokazu SuwaDepartment of Surgery, Yokosuka Kyosai Hospital, Yokosuka, Japan.

Yusuke SuwaDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.

Kazuya NakagawaDepartment of Gastroenterological Surgery, Graduate school of Medicine, Yokohama City University, Yokohama, Japan.

Mayumi OzawaDepartment of Gastroenterological Surgery, Graduate school of Medicine, Yokohama City University, Yokohama, Japan.

Itaru EndoDepartment of Gastroenterological Surgery, Graduate school of Medicine, Yokohama City University, Yokohama, Japan.

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6 · The paper itself

Abstract

purposeLong-term renal outcomes after ileostomy closure in patients undergoing curative colorectal tumor resection and diverting ileostomy remain unclear. We investigated renal outcomes and risk factors for chronic kidney disease (CKD) in this population.

methodsPatients who underwent colorectal tumor surgery after diverting ileostomy between January 2013 and December 2020 were analyzed. The serum creatinine (sCr) level and estimated glomerular filtration rate (eGFR) were monitored for up to three years after stoma closure. CKD progression was defined as an eGFR < 60 mL/min/1.73 m

resultsIn total, 533 patients were included: 112 with preoperative CKD and 421 without CKD. Among patients without preoperative CKD, 322 were followed up for 3 years after stoma closure. sCr levels and the eGFR showed persistent worsening even after stoma closure. Based on the eGFR at three years, patients were grouped into CKD and non-CKD groups. A multivariate analysis revealed that age ≥ 70 years old, a preoperative eGFR < 90 mL/min/1.73 m

conclusionsDiverting ileostomy poses a risk of a renal function decline even after stoma closure.

Indexed as

Colorectal NeoplasmsIleostomyKidneyPostoperative ComplicationsRenal Insufficiency, ChronicSurgical StomasAgedAge FactorsColorectal Surgical ProceduresCreatinineDisease ProgressionFemaleFollow-Up StudiesGlomerular Filtration RateHumansMaleCreatinineChronic kidney diseaseColorectal tumor surgeryDiverting ileostomyIleostomy-associated kidney injuryIleostomy closure

Identifiers

PMID42249907

DOI10.1007/s00595-026-03357-2

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