Evidence map›Paper›PMID 42249903›Full record

ReviewSurgery today2026

Optimizing axillary surgery for patients with clinically node-negative and node-positive breast cancer.

Shigeru Imoto, Akiko Matsumoto, Rikiya Nakamura, Norikazu Masuda, Hiroyuki Yasojima, Tatsuya Onishi, Shigeki Minami, Sayaka Kuba, Noriaki Wada, Hiromitsu Jinno and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shigeru ImotoDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan. imoto@ks.kyorin-u.ac.jp.
Akiko MatsumotoDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Rikiya NakamuraDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Norikazu MasudaDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Hiroyuki YasojimaDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Tatsuya OnishiDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Shigeki MinamiDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Sayaka KubaDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Noriaki WadaDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Hiromitsu JinnoDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Takahiro NakayamaDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.
Tomohiko AiharaDepartment of Breast Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-ku, Kawasaki, 210-0013, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is important that axillary surgery is optimized for de-escalation in the era of sentinel lymph node biopsy for early breast cancer. Several randomized trials of clinically node-negative breast cancer have demonstrated the non-inferiority of regional lymph node recurrence and distant metastasis in women aged ≥ 50 years with small tumors of the luminal subtype who did not undergo axillary surgery compared with those who underwent sentinel lymph node biopsy. Tailored axillary surgery has been attempted to personalize axillary management in patients with clinically node-positive breast cancer treated with neoadjuvant chemotherapy. Image-guided localization, such as clipping, has been shown to accurately diagnose lymph node involvement and reduce the rate of false negatives for sentinel lymph node biopsy. This technique also reduces regional lymph node recurrence, although regional nodal irradiation and adjuvant therapy are usually required for this purpose. In this review, we aimed to facilitate the optimization of axillary surgery for patients with clinically node-negative and node-positive breast cancer by discussing the findings of randomized trials and our own experiences at the Japanese Society for Sentinel Node Navigation Surgery.

Indexed as

AxillaBreast NeoplasmsLymph Node ExcisionLymph NodesFemaleHumansLymphatic MetastasisMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalRandomized Controlled Trials as TopicSentinel Lymph Node BiopsyBreast cancerRegional nodal irradiationSentinel lymph node biopsyTailored axillary surgeryTargeted axillary dissection

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.