Evidence map›Paper›PMID 42249898›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Determinants of olfactory cleft targeting in intranasal aerosol delivery: a combined computational and experimental study.

Shuo Wu, Yunjin Huang, Weiyuan Chen, Qinghe Yao, Qintai Yang, Gengchao Yang, Lelun Jiang

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shuo Wu *Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.
Yunjin Huang *School of Aeronautics and Astronautics, Sun Yat-sen University, Guangzhou, 510275, China.
Weiyuan Chen *School of Aeronautics and Astronautics, Sun Yat-sen University, Guangzhou, 510275, China.
Qinghe YaoSchool of Aeronautics and Astronautics, Sun Yat-sen University, Guangzhou, 510275, China.
Qintai YangDepartment of ENT, The 3rd Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
Gengchao YangSchool of Aeronautics and Astronautics, Sun Yat-sen University, Guangzhou, 510275, China.
Lelun JiangGuangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China. jianglel@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-5530-3266

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEfficient targeting of the olfactory cleft remains a key barrier to olfactory-targeted intranasal therapy and emerging nose-to-brain (N2B) delivery strategies. However, the upstream aerodynamic mechanisms governing aerosol access to the olfactory cleft during natural inhalation remain insufficiently characterized.

methodsA standardized representative sinonasal model reconstructed from high-resolution CT data of 32 healthy adults was used to evaluate the effects of administration plane, aerosol particle size, and administration angle on olfactory cleft deposition. Airflow and particle transport were simulated using a lattice Boltzmann-discrete particle method (LBM-DPM) framework across 108 parameterized conditions under natural inhalation. A geometry-consistent 3D-printed nasal model combined with radiotracer-based SPECT/CT imaging was used to experimentally validate deposition trends across administration planes.

resultsUnder nebulized delivery during natural inhalation, administration plane and aerosol particle size were the primary determinants of olfactory deposition efficiency, whereas administration angle exerted minimal influence. Shallow insertion facilitated upstream aerosol transport toward the olfactory cleft, with particles of approximately 7 μm achieving the highest and stable deposition efficiency across conditions. A modest interaction between insertion depth and particle size was observed without altering the optimal delivery configuration. In vitro radiotracer experiments demonstrated consistent deposition trends across administration planes compared with numerical simulations, supporting the model predictions.

conclusionUnder physiological inhalation, shallow nozzle positioning combined with intermediate-sized aerosol particles represents an optimal parameter configuration for olfactory-targeted intranasal aerosol delivery. These findings provide quantitative guidance for optimizing intranasal administration parameters and may support the development of nebulized delivery systems for olfactory-targeted therapies.

Indexed as

Nasal CavityAdministration, IntranasalAdultAerosolsComputer SimulationFemaleHumansMaleModels, AnatomicParticle SizePrinting, Three-DimensionalAerosolsAerosol depositionComputational fluid dynamicsLattice Boltzmann methodNose-to-brain deliveryOlfactory cleft

Identifiers

PMID42249898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.