Evidence map›Paper›PMID 42249891›Full record

Trial reportClinical and translational science2026

A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study of Adiponectin Agonist (PEG)-BHD1028 in People With Insulin Resistance.

Pablo Lapuerta, Brian B Kim

Abstract readRandomized Controlled TrialClinical Trial, Phase I
In one paragraph

Trial report in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pablo LapuertaLapuerta Consulting LLC, Skillman, New Jersey, USA.ORCID 0000-0003-0704-0251
Brian B KimEncuraGen Inc., Anyang, Republic of Korea.ORCID 0000-0001-7584-2892

Funding

Encuragen
6 · The paper itself

Abstract

Low adiponectin levels may contribute to insulin resistance. This first-in-human study evaluated adiponectin receptor agonist (PEG)-BHD1028 in subjects with insulin resistance. Adults with BMI ≥ 27 kg/m

Indexed as

AdiponectinInsulin ResistanceReceptors, AdiponectinAdultArea Under CurveBlood GlucoseBody Mass IndexC-PeptideDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansInsulinMaleMiddle AgedAdiponectinADIPOQ protein, humanBlood GlucoseC-PeptideInsulinReceptors, AdiponectinadiponectinBHD1028insulin resistanceobesitypost‐prandial glucose

Identifiers

PMID42249891
PMCPMC13242176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.