ArticleMuscle & nerve2026
Quantitative MRI Assessment of Myotoxin-Induced Skeletal Muscle Damage of mdx Mice.
Article in Muscle & nerve, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
INTRODUCTION/
aimsAlthough magnetic resonance imaging (MRI) has been extensively applied in dystrophic muscle, longitudinal characterization of multiple quantitative MRI parameters during degeneration and regeneration remains limited. This study aimed to longitudinally characterize changes in quantitative MRI parameters in control and dystrophic mouse muscles following myotoxin-induced myonecrosis using multi-parametric MRI (mpMRI).
methodsmpMRI was performed at 14 Tesla in mdx
resultsMean T1 values decreased, reaching minima at day 5 in ctrl (3.05 ± 0.67 s) and day 3 in mdx DISCUSSION: mpMRI revealed distinct, time-dependent changes following myotoxin injury, demonstrating the added value of mpMRI as a noninvasive approach for sensitively characterizing the temporal evolution of quantitative MRI parameters following myotoxin-induced muscle injury in both control and dystrophic mice.
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