Evidence map›Paper›PMID 42249623›Full record

ArticleInternational journal of STD & AIDS2026

A case of transient hepatocellular injury in an HIV monoclonal antibody trial.

Ishana Harkoo, Parveen Sobia, Derseree Archary, Nigel Garrett, Sharana Mahomed

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of STD & AIDS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ishana HarkooCAPRISA, Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Parveen SobiaCAPRISA, Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Derseree ArcharyCAPRISA, Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Nigel GarrettCAPRISA, Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Sharana MahomedCAPRISA, Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.ORCID 0009-0005-1449-160X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis and management of acute hepatocellular injury continue to pose significant challenges. Clinicians depend on both clinical and laboratory findings, alongside the exclusion of other potential aetiologies, to make a diagnosis. We describe a case of transient marked hepatocellular injury in a phase 1 clinical trial participant exposed to anti-HIV monoclonal antibodies. The trial was registered with the Pan African Clinical Trial Registry (PACTR 201808919297244) on 29 August 2018.

Indexed as

Antibodies, MonoclonalAnti-HIV AgentsChemical and Drug Induced Liver InjuryHIV AntibodiesHIV InfectionsLiverAdultHumansMaleAntibodies, MonoclonalAnti-HIV AgentsHIV AntibodiesHIVmonoclonal antibodiestransaminase elevationtrial

Identifiers

PMID42249623
PMCPMC13498743

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.