Evidence map›Paper›PMID 42249616›Full record

ArticleActa physiologica (Oxford, England)2026

Clustering Properties of Neuronal Ryanodine Receptor 2 and Remodeling in the APP/PS1 Mouse Model of Alzheimer's Disease.

Michelle L Munro, Ruben Vergara Silva, Shane M Ohline, Ei Phyo Khaing, Joan A Chan, Mohamed F Ibrahim, Tausi F Tausi, Wickliffe C Abraham, Peter P Jones

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Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michelle L MunroDepartment of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0003-0089-3956
Ruben Vergara SilvaDepartment of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Shane M OhlineDepartment of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0001-7716-5055
Ei Phyo KhaingDepartment of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Joan A ChanDepartment of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Mohamed F IbrahimDepartment of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Tausi F TausiDepartment of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Wickliffe C AbrahamBrain Health Research Centre, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0001-9919-0622
Peter P JonesDepartment of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0001-7977-1737

Funding

Health Research Council of New Zealand 20/370Health Research Council of New Zealand 20/625Marsden Fund UOO2009Neurological Foundation of New Zealand 2011 PGR
6 · The paper itself

Abstract

aimThe ryanodine receptor (RyR2) is an intracellular Ca

methodsUsing super-resolution imaging, we assessed RyR2 organization in CA1 pyramidal neurons of wild-type mice. Furthermore, we used the APP/PS1 mouse model of Alzheimer's disease (AD) to assess whether there is nanoscale remodeling of RyR2 in a setting associated with pathological Ca

resultsHere, we provide the first identification and detailed characterization of RyR2 clusters in central nervous system neurons, which are comparable to those reported in the heart. Moreover, we observed a decrease in RyR2 cluster size and reduced CRU organization in AD mice at an age associated with high plaque burden and cognitive deficits. This remodeling is analogous to that reported in pathological states in the heart.

conclusionTogether, these findings implicate the nanoscale remodeling of RyR2 clusters and CRUs as a novel mechanism underlying Ca

Indexed as

Alzheimer DiseaseNeuronsRyanodine Receptor Calcium Release ChannelAmyloid beta-Protein PrecursorAnimalsCalciumCalcium SignalingDisease Models, AnimalMiceMice, TransgenicPresenilin-1Amyloid beta-Protein PrecursorCalciumPresenilin-1ryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelAlzheimer's diseaseCA1 hippocampal neuronscalcium channelsdSTORMRyR2super‐resolution imaging

Identifiers

PMID42249616
PMCPMC13241622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.