Evidence map›Paper›PMID 42249593›Full record

ArticleThe Journal of comparative neurology2026

Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula.

Aashka K Popat, Rhiana C Simon, Beatriz B Aoyama, Ahana Wokhlu, Aliza T Ehrlich, Corey C Harwell, Elyssa B Margolis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Aashka K PopatUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.ORCID https://orcid.org/0009-0003-3764-7131
Rhiana C SimonUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-6672-3816
Beatriz B AoyamaUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-1458-5516
Ahana WokhluUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.ORCID https://orcid.org/0009-0000-5133-1289
Aliza T EhrlichUCSF Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-7507-1100
Corey C HarwellUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-8043-5869
Elyssa B MargolisUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-8777-302X

Funding

The impact of early life opioid exposure on the molecular and functional trajectories of septal cell typesR01DA059388 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COREY C HARWELL, Garret D Stuber · 2023 to 2026
$3.1M
Temporal Specification of Basal Forebrain CircuitryR37MH119156 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COREY C HARWELL · 2024 to 2026
$2.1M
Direct lateral habenula projection to a critical pain transmission circuitR01NS134981 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elyssa Margolis · 2024 to 2026
$1.9M
The role of the VTA-lateral habenula circuit in opioid mediated behaviorsR01DA042025 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARGOLIS, ELYSSA · 2017 to 2021
$1.8M
Neuronal Gαi-GPCR targeting to primary cilia and impact on cAMP mediated transcriptionK01MH123757 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EHRLICH, ALIZA TOBY · 2020 to 2024
$792k
A.P. Giannini FoundationCoordenação de Aperfeiçoamento de Pessoal de Nível Superior grant 88887.878571/2023-00NIDA NIH HHS R01 DA042025NIDA NIH HHS R01DA042025NIDA NIH HHS R01 DA059388NIDA NIH HHS R01DA059388NIMH NIH HHS K01MH123757NIMH NIH HHS R37MH119156NINDS NIH HHS R01 NS134981NINDS NIH HHS R01NS134981Painless Research FoundationState of California for medical research on alcohol and substance use
6 · The paper itself

Abstract

The habenula (Hb) has high-intensity mu opioid binding and receptor (MOR) expression. It contains medial and lateral subdivisions (MHb and LHb, respectively), yet the details of MOR localization across these regions remain debated. MHb and LHb participate in largely non-overlapping neural circuits; therefore, accurately resolving MOR expression across them is critical for understanding how MOR ligands impact behaviors. Here we utilized in situ hybridization (ISH) and immunocytochemistry (ICC) to systematically map Oprm1 mRNA and MOR protein throughout the habenular complex. We studied rat and mouse tissue to evaluate expression across two common research species. We also performed parallel mapping in Oprm1-

Indexed as

HabenulaReceptors, Opioid, muRNA, MessengerAnimalsIn Situ HybridizationMaleMiceMice, Inbred C57BLMice, TransgenicRatsRats, Sprague-DawleySpecies SpecificityOprm1 protein, ratReceptors, Opioid, muRNA, Messengeraddictionepithalamushabenulaopioid receptorOprm1painwithdrawal

Identifiers

PMID42249593
PMCPMC13241623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.