ArticlePest management science2026
Overexpression of novel CYP6ER1 variants mediates the resistance of Nilaparvata lugens to sulfoxaflor and the cross-resistance to neonicotinoid insecticides.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious field-based resistance monitoring and indoor selection studies by the present authors indicated significant cross-resistance between the sulfoximine insecticide sulfoxaflor and neonicotinoid insecticides in the brown planthopper, Nilaparvata lugens. However, the mechanism of cross-resistance has remained unclear.
resultsIn this study, we investigated the involvement of cytochrome P450 monooxygenases in cross-resistance between neonicotinoids and sulfoxaflor with a particular focus on overexpression and qualitative changes to CYP6ER1. Real-time quantitative PCR results show that the mRNA and DNA levels of CYP6ER1 in the sulfoxaflor-resistant (SFX-R) strain (G
conclusionThe results showed that the overexpression of CYP6ER1 novel variants was closely associated with the resistance of N. lugens to sulfoxaflor and the cross-resistance to neonicotinoid insecticides. These findings extend understanding of the molecular basis of high-level cross-resistance between sulfoxaflor and neonicotinoids in N. lugens. © 2026 Society of Chemical Industry.
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