ArticleMagnetic resonance in medicine2026
High-Temporal-Resolution Monitoring of Creatine and Phosphocreatine Dynamics in Skeletal Muscle Using Ultrafast Z-Spectroscopy (UFZ) CEST MRI at 3T.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the feasibility of High-Temporal-Resolution (HTR) Ultrafast Z-spectrum (UFZ) CEST MRI for monitoring the dynamic fluctuations of phosphocreatine (PCr) and creatine (Cr) in human skeletal muscle (SM) at 3 T during and after exercise.
methodsHTR UFZ-CEST MRI of SM was achieved using a 1D spatial and spectral encoding with a 2D turbo spin-echo readout. Five healthy subjects performed in-magnet plantar flexion exercise, and dynamic changes in Amide, PCr, and partial PCr-mixed creatine (Cr
resultsDynamic CEST contrasts with 7.6 s temporal resolution revealed PCr depletion (-76.9% ± 17.7%) and concomitant Cr elevation (469.0% ± 116.3%) during exercise, followed by exponential PCr recovery and Cr decay during recovery. The post-exercise recovery constants for Cr and PCr CEST were 61.5 ± 45.6 s and 73.3 ± 66.1 s, respectively. Using two-step Bloch-McConnell simulation based on the experimental lineshape and CEST changes, we estimated an exchange rate of 150 ± 70 s
conclusionThese results establish UFZ-CEST as a rapid, noninvasive method for mapping Cr/PCr dynamics in human SM and provide a foundation for clinical assessment of mitochondrial function.
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