Evidence map›Paper›PMID 42249427›Full record

ArticleJournal of nanobiotechnology2026

Temporal and spatial-adapted metal ions delivery system for spinal cord injury repair with Mg-Zn-doped bilayer bioactive glasses.

Su Xinjin, Wu Yuantao, Xu Zheng, Kong Qingjie, Huo Shicheng, Chen Xiongsheng, Zhu Chao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Su Xinjin *Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wu Yuantao *Department of Spine Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
Xu Zheng *Department of Orthopaedics, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.
Kong QingjieDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Huo ShichengDepartment of Orthopaedics, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Chen XiongshengDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. chenxiongsheng@vip.sohu.com.
Zhu ChaoDepartment of Spine Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zhuchao@renji.com.

Funding

National Natural Science Foundation of China No. 82272496the Academic Enhancement Support Program of Hainan Medical University No. XSTS2026039the Shanghai Committee of Science and Technology No. 25ZR1401299, 23Y11903700
6 · The paper itself

Abstract

In clinical practice, ion supplementation therapy has demonstrated excellent clinical efficacy in spinal cord injury (SCI) repair. However, due to the spatiotemporal dynamics of ion imbalance following SCI, targeted phase-adapted ion supplementation strategies for SCI repair remain challenging. To address this issue, a spatiotemporally adapted metal-ion delivery system, Mg-Zn-doped bilayer bioactive glasses (Mg-Zn/BGs), was developed. It had a diameter of approximately 125 nm and comprised an Mg/BGs outer shell and a Zn/BGs inner core. The core-shell structure of Mg-Zn/BGs enables phase-specific sustained release of Mg

Indexed as

GlassMagnesiumSpinal Cord InjuriesZincAnimalsCell ProliferationIonsMacrophagesMiceMice, Inbred C57BLNerve RegenerationIonsMagnesiumZincBilayer bioactive glassesInflammationMg-Zn-dopedNeural regenerationSpinal cord injury

Identifiers

PMID42249427
PMCPMC13459422

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.